HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PTPRC (P06800)
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)
Gene: PTPRC

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.755

The method score is based on:

Property Details
Experiments 8570203, 9581568
Identification Methods coimmunoprecipitation, phosphatase assay
Interaction Type association, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms GO:0005102 - signaling receptor binding
GO:0030217 - T cell differentiation
GO:0042492 - gamma-delta T cell differentiation
GO:0045121 - membrane raft
GO:0045588 - positive regulation of gamma-delta T cell differentiation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 509
Mm

1 1293
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024