HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.757

The method score is based on:

Property Details
Experiments 9822663, 11262396
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, C1_1~SH2, SH2~SH2, SH2~SH3_1, PH~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0031295 - T cell costimulation
GO:0035556 - intracellular signal transduction
GO:0038096 - Fc-gamma receptor signaling pathway involved in phagocytosis
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 537
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024