HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: NUMBL (Q9Y6R0)
Numb-like protein (Numb-related protein) (Numb-R)
Gene: NUMBL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 609
+	Hs
		411643 LCK_HUMAN (1-509): 0: 661: 100.00		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Hs
		434112 LYN_HUMAN (1-509): 0: 582: 62.72		NUMBL_HUMAN (1-609): 3.31e-87: 285: 100.00
+	Hs
		433649 LYN_HUMAN (1-509): 0: 582: 62.72		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Hs
		253523 LCK_HUMAN (1-509): 0: 661: 100.00		CAPON_HUMAN (68-316): 6.44e-39: 151: 19.05
+	Hs
		253524 FYN_HUMAN (30-507): 0: 586: 59.01		CAPON_HUMAN (68-316): 6.44e-39: 151: 19.05
+	Hs
		412433 FYN_HUMAN (30-507): 0: 586: 59.01		MYO16_HUMAN (138-604): 1.06e-35: 146: 12.92
+	Hs
		203198 LCK_HUMAN (1-509): 0: 661: 100.00		SYNJ1_HUMAN (217-607): 6.26e-12: 70.9: 11.21
+	Mm
		763385 FYN_MOUSE (30-507): 0: 586: 58.80		DAB1_MOUSE (72-605): 3.26e-32: 133: 15.05
+	Hs
		412132 FYN_HUMAN (30-507): 0: 586: 59.01		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		522909 SRC_HUMAN (20-507): 0: 586: 55.00		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Mm
		403429 SRC_MOUSE (28-507): 0: 583: 57.05		DAB1_MOUSE (72-605): 3.26e-32: 133: 15.05
+	Hs
		454823 FGR_HUMAN (1-507): 0: 579: 52.76		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Mm
		956225 YES_MOUSE (26-507): 0: 576: 57.85		DAB1_MOUSE (72-605): 3.26e-32: 133: 15.05
+	Dm
		337651 ABL_DROME (43-502): 3.42e-171: 525: 42.34		DAB_DROME (67-470): 1.83e-43: 169: 18.40
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (173-497): 2.24e-24: 111: 11.25
+	Ce
		106650 SRC1_CAEEL (1-508): 8.64e-179: 514: 44.84		CED6_CAEEL (64-430): 7.43e-32: 131: 15.72