HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 2725
+	Hs
		337473 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		412006 FYN_HUMAN (1-537): 0: 643: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		522770 SRC_HUMAN (1-537): 0: 598: 68.21		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		337345 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598078 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		521454 SRC_HUMAN (1-537): 0: 598: 68.21		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211480 SRC_HUMAN (1-537): 0: 598: 68.21		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		411676 LCK_HUMAN (40-535): 0: 551: 57.60		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		433700 LYN_HUMAN (1-535): 0: 535: 54.48		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		362685 FYN_HUMAN (1-537): 0: 643: 100.00		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		521527 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		993249 PTK6_HUMAN (83-529): 4.09e-152: 444: 42.92		ACTN3_HUMAN (23-388): 4.53e-120: 406: 27.63
+	Hs
		362705 YES_HUMAN (1-537): 0: 591: 71.61		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83