Protein: IQGA3
Ras GTPase-activating-like protein IQGAP3

Gene: IQGA3, IQGAP3
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q86VI3

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0005096 - GTPase activator activity
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955338

CDC42
Cell division control protein 42 homolog

4

20

High-throughput

0.903

High

988494

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.847

High

953538

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.789

High

878498

PAXI
Paxillin

2

9

High-throughput

0.737

High

1290495

ANLN
Anillin

5

7

High-throughput

0.712

High

457529

TBB5
Tubulin beta chain

1

6

High-throughput

0.691

High

828390

PEX19
Peroxisomal biogenesis factor 19

3

3

High-throughput

0.667

High

650270

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.665

High

1140099

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.656

High

952594

MYL6
Myosin light polypeptide 6

2

20

High-throughput

0.628

High

1092992

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

317345

ACL6B
Actin-like protein 6B

1

20

High-throughput

0.618

High

126675

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

363512

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

466336

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

962226

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978127

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1290491

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1290509

NINL
Ninein-like protein

1

16

High-throughput

0.618

High

555832

MYL4
Myosin light chain 4

2

20

High-throughput

0.601

High

516355

CALM1
Calmodulin-1

1

13

High-throughput

0.575

High

396437

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

573972

MYL6B
Myosin light chain 6B

2

20

High-throughput

0.571

High

412192

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

601353

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

1254466

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1290470

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1290487

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

158463

RFXK
DNA-binding protein RFXANK

1

12

High-throughput

0.536

High

300785

KRT38
Keratin, type I cuticular Ha8

1

3

High-throughput

0.536

High

372461

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.536

High

384469

CRYAA
Alpha-crystallin A chain

1

10

High-throughput

0.536

High

391322

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

564005

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

777513

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.536

High

872490

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

905608

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

1041772

PPARD
Peroxisome proliferator-activated receptor delta

1

3

High-throughput

0.536

High

1153185

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

5

High-throughput

0.536

High

1243012

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.536

High

1290462

KIFA3
Kinesin-associated protein 3

1

8

High-throughput

0.536

High

1290463

TRI52
E3 ubiquitin-protein ligase TRIM52

1

9

High-throughput

0.536

High

1290465

ARMC5
Armadillo repeat-containing protein 5

1

7

High-throughput

0.536

High

1290498

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

1290502

KLH14
Kelch-like protein 14

1

2

High-throughput

0.536

High

1290506

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

2

High-throughput

0.536

High

1290507

HECD1
E3 ubiquitin-protein ligase HECTD1

2

9

Small-scale

0.533

High

1290503

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

7

High-throughput

0.515

High

442385

GELS
Gelsolin

1

8

High-throughput

0.515

High

1279601

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

11

High-throughput

0.515

High

516429

CALM2
Calmodulin-2

1

13

High-throughput

0.514

High

516551

CALM3
Calmodulin-3

1

13

High-throughput

0.514

High

296799

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

334204

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1186175

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

1290461

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1290482

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1290485

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1290488

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1290500

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

0

High-throughput

0.513

High

508225

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

167306

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

131068

TULP2
Tubby-related protein 2

1

1

High-throughput

0.489

High

239111

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.489

High

338886

CBX6
Chromobox protein homolog 6

1

1

High-throughput

0.489

High

355085

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

19

High-throughput

0.489

High

503619

TFPT
TCF3 fusion partner

1

1

High-throughput

0.489

High

846763

GRK6
G protein-coupled receptor kinase 6

1

10

High-throughput

0.489

High

1091192

FOXD4
Forkhead box protein D4

1

4

High-throughput

0.489

High

1289351

ST32C
Serine/threonine-protein kinase 32C

1

11

High-throughput

0.489

High

1290453

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.489

High

1290455

ACRBP
Acrosin-binding protein

1

1

High-throughput

0.489

High

1290472

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

1

High-throughput

0.489

High

1290475

PSKH2
Serine/threonine-protein kinase H2

1

17

High-throughput

0.489

High

1290477

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

1290504

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

1290514

RPKL1
Ribosomal protein S6 kinase-like 1

1

15

High-throughput

0.489

High

159728

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

15

High-throughput

0.479

High

223161

PRC1
Protein regulator of cytokinesis 1

1

12

High-throughput

0.479

High

346023

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

353428

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

384693

CRYAB
Alpha-crystallin B chain

1

10

High-throughput

0.479

High

487485

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

626272

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

15

High-throughput

0.479

High

934813

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.479

High

1035746

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

1040842

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1113577

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1161316

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

High-throughput

0.479

High

1178228

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1276431

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1290459

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1290471

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1290476

PASK
PAS domain-containing serine/threonine-protein kinase

1

5

High-throughput

0.479

High

1290489

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1290490

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

1290493

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.479

High

1290505

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1290508

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

1232319

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

6

High-throughput

0.470

High

109448

G5E9A7
DM1 locus, WD repeat containing

1

8

High-throughput

0.470

High

1290496

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

97287

E9PSE9
Coiled-coil domain containing 198

1

1

High-throughput

0.451

High

351131

ECD
Protein ecdysoneless homolog

1

1

High-throughput

0.445

High

437590

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

20

High-throughput

0.445

High

920083

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.445

High

943981

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

10

High-throughput

0.445

High

1179226

ERC6L
DNA excision repair protein ERCC-6-like

1

8

High-throughput

0.445

High

1209341

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1290449

CUL9
Cullin-9

1

4

High-throughput

0.445

High

1290466

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

High-throughput

0.445

High

1290499

SPN90
NCK-interacting protein with SH3 domain

1

1

High-throughput

0.445

High

1290497

FAME
Factor associated with metabolism and energy

1

1

High-throughput

0.439

High

293951

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

768565

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

1015251

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.437

High

1100076

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.437

High

1248981

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1250164

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1290451

SLX4
Structure-specific endonuclease subunit SLX4

1

8

High-throughput

0.437

High

1290460

ESR2
Estrogen receptor beta

1

16

High-throughput

0.437

High

1290464

CLUA1
Clusterin-associated protein 1

1

2

High-throughput

0.437

High

1290478

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.437

High

1290481

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.437

High

1290486

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

9

High-throughput

0.437

High

1290510

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.437

High

321924

FRYL
Protein furry homolog-like

1

0

High-throughput

0.426

High

1139336

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1290479

THUM3
tRNA

1

0

High-throughput

0.426

High

1290494

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.426

High

58852

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.407

High

126138

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.407

High

208530

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

High-throughput

0.407

High

344234

PTBP3
Polypyrimidine tract-binding protein 3

1

3

High-throughput

0.407

High

653415

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

844817

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.407

High

844940

EAA2
Excitatory amino acid transporter 2

1

2

High-throughput

0.407

High

877689

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

1133786

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.407

High

1197812

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.407

High

1239508

ZNT6
Zinc transporter 6

1

4

High-throughput

0.407

High

1242841

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.407

High

1251770

S39A5
Zinc transporter ZIP5

1

4

High-throughput

0.407

High

1253623

PKHG7
Pleckstrin homology domain-containing family G member 7

1

9

High-throughput

0.407

High

1290450

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.407

High

1290457

NEK7
Serine/threonine-protein kinase Nek7

1

10

High-throughput

0.407

High

1290484

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

3

High-throughput

0.407

High

1290501

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1290512

DCAF1
DDB1- and CUL4-associated factor 1

1

9

High-throughput

0.407

High

1233749

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.328

High

221039

HAIR
Lysine-specific demethylase hairless

1

0

High-throughput

0.279

Low

261518

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

289790

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

690038

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

1147936

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1192194

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1207229

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1238946

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.279

Low

1290452

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1290456

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.279

Low

1290458

BSND
Barttin

1

0

High-throughput

0.279

Low

1290467

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1290468

HES6
Transcription cofactor HES-6

1

0

High-throughput

0.279

Low

1290469

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1290474

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1290483

BC11B
B-cell lymphoma/leukemia 11B

1

0

High-throughput

0.279

Low

1290492

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

1290513

Q9Y649
GW128

1

0

High-throughput

0.268

Low

298607

RAD17
Cell cycle checkpoint protein RAD17

1

0

Small-scale

0.249

Low

1290473

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

66627

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.232

Low

187125

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.232

Low

1185856

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1238995

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.232

Low

1290454

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

1290480

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.232

Low

1290511

KAD6
Adenylate kinase isoenzyme 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025