HitPredict

Interactor 1: GELS (P06396)
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
Gene: GSN

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0030027 - lamellipodium and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 782 Hs			1 377
+	Hs
		413941 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		413874 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		413884 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		413885 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		413886 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Oc
		101997 G1U9R8_RABIT (44-782): 0: 1156: 94.59		ACTB_RABIT (4-377): 0: 595: 93.85
+	Hs
		1122544 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		892149 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		930076 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932481 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		933081 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Hs
		915546 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Dm
		501491 QUAI_DROME (41-781): 0: 639: 23.78		ACT1_DROME (1-377): 0: 597: 93.90
+	Hs
		891735 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		929839 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932132 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Dm
		950116 FLII_DROME (399-764): 4.5e-55: 207: 23.90		ACT6_DROME (1-377): 0: 593: 92.84
+	Bt
		221227 SVIL_BOVIN (565-781): 9.32e-25: 113: 23.26		ACTB_BOVIN (4-377): 0: 598: 94.12
+	Hs
		313786 SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86		ACTB_HUMAN (4-377): 0: 598: 94.12