HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17353931, 14743216
Identification Methods	anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 716
+	Hs
		1150633 MRCKG_HUMAN (3-285): 1.48e-14: 75.7: 10.65		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		167444 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Rn
		1186812 MRCKB_RAT (3-285): 1.56e-12: 69.5: 14.09		MRCKB_RAT (7-705): 9.57e-107: 359: 16.69
+	Hs
		1071723 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		KS6A2_HUMAN (6-290): 2.47e-89: 297: 21.95
+	Hs
		262224 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		ULK1_HUMAN (2-221): 1.05e-23: 109: 31.72
+	Hs
		262220 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		ULK1_HUMAN (2-221): 1.05e-23: 109: 31.72