HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: MD1L1 (Q9Y6D9)
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
Gene: MAD1L1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	25416956, 21516116, 25910212, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 285 Hs			1 718
+	Hs
		451336 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MD1L1_HUMAN (1-718): 9.25e-62: 221: 100.00
+	Hs
		1138404 Q5VU62_HUMAN (128-285): 1.66e-39: 137: 100.00		MD1L1_HUMAN (1-718): 9.25e-62: 221: 100.00
+	Dm
		419108 TPM1_DROME (2-282): 8.67e-51: 171: 45.97		MYSN_DROME (131-716): 5.22e-24: 110: 14.52
+	Mm
		101558 LAMA1_MOUSE (4-280): 3.27e-51: 182: 14.84		F8VQJ3_MOUSE (52-530): 3.56e-14: 78.8: 16.45
+	Hs
		418895 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		451201 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		1137917 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		MRCKA_HUMAN (164-708): 6.22e-43: 170: 17.69
+	Hs
		434354 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		148289 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		CTRO_HUMAN (54-632): 5.17e-13: 75: 15.98
+	Hs
		451288 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		DLG5_HUMAN (125-628): 3.83e-12: 72.3: 15.98
+	Hs
		419011 TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		451293 TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		724765 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		434415 TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		148661 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		CTRO_HUMAN (54-632): 5.17e-13: 75: 15.98
+	Hs
		932031 TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Mm
		358674 LAMB1_MOUSE (3-211): 2.99e-16: 80.8: 19.05		LAMC1_MOUSE (43-530): 3.84e-14: 78.8: 16.18
+	Rn
		222476 MRCKB_RAT (3-285): 1.56e-12: 69.5: 14.09		MRCKA_RAT (1-359): 5.67e-11: 68.3: 11.92
+	Rn
		1186812 MRCKB_RAT (3-285): 1.56e-12: 69.5: 14.09		MRCKB_RAT (1-400): 2.49e-09: 63.1: 13.22
+	Hs
		1268126 MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87