HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: RN168 (Q8IYW5)
E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)
Gene: RNF168

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	37503842, 27153538, 29233925, 31501315, 31376412, 33022275, 19203579, 33710666, 36331508
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~Prok-RING_4
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 130 Hs			1 571
+	Hs
		1232693 H2A2A_HUMAN (1-130): 3.71e-68: 203: 96.92		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1272803 H2A3_HUMAN (1-130): 4.18e-68: 202: 99.23		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		502425 H2A1_HUMAN (1-130): 4.52e-68: 202: 98.46		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1162827 H2A2C_HUMAN (1-130): 1.96e-65: 196: 95.39		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		591726 H2AX_HUMAN (1-130): 5.35e-64: 192: 88.06		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1232698 H2A2A_HUMAN (1-130): 3.71e-68: 203: 96.92		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		419092 H2A1B_HUMAN (1-130): 5.44e-68: 202: 100.00		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		1162838 H2A2C_HUMAN (1-130): 1.96e-65: 196: 95.39		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		1370944 H2A1H_HUMAN (1-128): 2.08e-67: 201: 98.44		PRG4_HUMAN (4-544): 1.1e-10: 66.9: 9.23
+	Hs
		419108 H2A1B_HUMAN (1-130): 5.44e-68: 202: 100.00		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91
+	Hs
		502455 H2A1_HUMAN (1-130): 4.52e-68: 202: 98.46		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91
+	Hs
		1361895 H2A1H_HUMAN (1-128): 2.08e-67: 201: 98.44		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91