HitPredict

Interactor 1: LDHB (P07195)
L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)
Gene: LDHB

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.550

Property	Details
Experiments	24725412
Identification Methods	tandem affinity purification, protein kinase assay
Interaction Type	association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 2527
+	Hs
		1130163 Q5U077_HUMAN (1-334): 5.62e-161: 454: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		334210 LDHA_HUMAN (1-332): 3.36e-160: 452: 75.60		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130232 LDH6A_HUMAN (1-332): 4.92e-153: 434: 65.36		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		777456 MDHC_HUMAN (23-329): 4.71e-98: 294: 20.87		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		129 A0A024R4K3_HUMAN (11-334): 3.52e-96: 290: 18.92		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		777586 MDHM_HUMAN (11-334): 3.52e-96: 290: 18.92		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		201252 MDHC_HUMAN (23-329): 4.71e-98: 294: 20.87		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201253 MDHM_HUMAN (11-334): 3.52e-96: 290: 18.92		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83