Protein: PAK6
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)

Gene: PAK6
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q9NQU5

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955638

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.924

High

354784

PAK4
Serine/threonine-protein kinase PAK 4

4

19

High-throughput

0.903

High

988740

RAC1
Ras-related C3 botulinum toxin substrate 1

4

20

Small-scale

0.893

High

1209693

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

12

Small-scale

0.873

High

1182867

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

9

High-throughput

0.778

High

1433523

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

High-throughput

0.725

High

1396637

RHOV
Rho-related GTP-binding protein RhoV

2

20

High-throughput

0.700

High

972035

1433E
14-3-3 protein epsilon

4

12

High-throughput

0.699

High

443531

CDK1
Cyclin-dependent kinase 1

1

13

High-throughput

0.698

High

1438781

NEK6
Serine/threonine-protein kinase Nek6

1

16

High-throughput

0.698

High

920509

DAPK1
Death-associated protein kinase 1

1

12

High-throughput

0.692

High

912517

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

19

High-throughput

0.691

High

1110412

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

10

High-throughput

0.691

High

1157946

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.691

High

520395

ANDR
Androgen receptor

3

15

Small-scale

0.678

High

966912

1433G
14-3-3 protein gamma

3

20

High-throughput

0.675

High

1386117

LRC45
Leucine-rich repeat-containing protein 45

1

7

High-throughput

0.665

High

1158190

MK14
Mitogen-activated protein kinase 14

1

20

High-throughput

0.656

High

922286

LIMK1
LIM domain kinase 1

1

20

Small-scale

0.647

High

1447289

PAK6
Serine/threonine-protein kinase PAK 6

1

16

Small-scale

0.647

High

990774

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

1028405

MDM2
E3 ubiquitin-protein ligase Mdm2

2

3

Small-scale

0.624

High

691463

1433T
14-3-3 protein theta

2

20

High-throughput

0.621

High

658935

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

1

Small-scale

0.619

High

644591

TENX
Tenascin-X

1

6

High-throughput

0.618

High

1419421

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.618

High

374951

RASH
GTPase HRas

1

14

High-throughput

0.618

High

461959

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468832

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

613195

EGR1
Early growth response protein 1

1

7

High-throughput

0.618

High

936458

AFAD
Afadin

1

10

High-throughput

0.618

High

423258

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.602

High

269388

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

255487

SNX2
Sorting nexin-2

1

8

High-throughput

0.541

High

64132

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

High-throughput

0.536

High

144322

ACACB
Acetyl-CoA carboxylase 2

1

12

High-throughput

0.536

High

174111

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.536

High

230118

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.536

High

547699

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

High-throughput

0.536

High

641036

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

6

High-throughput

0.536

High

697669

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.536

High

730275

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

755798

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.536

High

774649

BASI
Basigin

1

5

High-throughput

0.536

High

786273

LONM
Lon protease homolog, mitochondrial

1

7

High-throughput

0.536

High

852862

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

6

High-throughput

0.536

High

910336

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.536

High

920895

ACLY
ATP-citrate synthase

1

4

High-throughput

0.536

High

964750

DCAF7
DDB1- and CUL4-associated factor 7

1

6

High-throughput

0.536

High

992980

RACK1
Small ribosomal subunit protein RACK1

1

12

High-throughput

0.536

High

1049819

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1199842

AGK
Acylglycerol kinase, mitochondrial

1

1

High-throughput

0.536

High

1215370

DCAF8
DDB1- and CUL4-associated factor 8

1

4

High-throughput

0.536

High

1239383

ESRP1
Epithelial splicing regulatory protein 1

1

15

High-throughput

0.536

High

1336350

GIMA8
GTPase IMAP family member 8

1

1

High-throughput

0.536

High

1359544

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.536

High

1371546

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.536

High

1371716

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.536

High

1383785

TTC28
Tetratricopeptide repeat protein 28

1

7

High-throughput

0.536

High

1393322

SAHH3
Adenosylhomocysteinase 3

1

3

High-throughput

0.536

High

1402524

NEB2
Neurabin-2

1

10

High-throughput

0.536

High

1164401

TPD53
Tumor protein D53

1

0

High-throughput

0.518

High

466062

ANXA6
Annexin A6

1

8

High-throughput

0.515

High

1430900

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.513

High

397014

ESR1
Estrogen receptor

1

16

Small-scale

0.501

High

1447290

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

1098333

SEM3B
Semaphorin-3B

1

1

High-throughput

0.494

High

699164

CALX
Calnexin

1

2

High-throughput

0.489

High

1432582

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.489

High

556362

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

730908

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

1348527

LNX1
E3 ubiquitin-protein ligase LNX

1

9

Small-scale

0.479

High

1400148

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

9

High-throughput

0.445

High

1417567

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

1041704

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025