Protein: PAK2
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]

Gene: PAK2
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q13177

Gene Ontology (top 5):
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0003300 - cardiac muscle hypertrophy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955116

CDC42
Cell division control protein 42 homolog

12

20

Small-scale

0.980

High

1097195

ARHG6
Rho guanine nucleotide exchange factor 6

9

16

Small-scale

0.971

High

1097189

ARHG7
Rho guanine nucleotide exchange factor 7

7

16

Small-scale

0.970

High

1097231

RHOJ
Rho-related GTP-binding protein RhoJ

7

20

High-throughput

0.968

High

988331

RAC1
Ras-related C3 botulinum toxin substrate 1

7

20

Small-scale

0.965

High

1097245

GIT1
ARF GTPase-activating protein GIT1

5

13

Small-scale

0.922

High

1096420

PAK1
Serine/threonine-protein kinase PAK 1

5

18

High-throughput

0.919

High

1097182

PAK2
Serine/threonine-protein kinase PAK 2

5

17

Small-scale

0.912

High

1097229

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

20

High-throughput

0.861

High

1097238

PLK2
Serine/threonine-protein kinase PLK2

3

17

High-throughput

0.861

High

1097191

GIT2
ARF GTPase-activating protein GIT2

3

13

High-throughput

0.855

High

1097190

SCRIB
Protein scribble homolog

2

6

High-throughput

0.811

High

400759

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.806

High

1097211

RHOU
Rho-related GTP-binding protein RhoU

2

20

High-throughput

0.789

High

581019

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

Small-scale

0.768

High

241567

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.754

High

977975

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

222073

NCK2
Cytoplasmic protein NCK2

7

20

High-throughput

0.747

High

473411

HCK
Tyrosine-protein kinase HCK

1

18

Small-scale

0.747

High

557274

SRC
Proto-oncogene tyrosine-protein kinase Src

1

18

Small-scale

0.747

High

593983

NCK1
SH2/SH3 adapter protein NCK1

6

20

Small-scale

0.730

High

362273

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.724

High

922249

LIMK1
LIM domain kinase 1

1

20

Small-scale

0.710

High

578472

BRAF
Serine/threonine-protein kinase B-raf

1

17

High-throughput

0.698

High

1040280

DYST
Dystonin

1

11

High-throughput

0.698

High

724680

MK04
Mitogen-activated protein kinase 4

1

8

High-throughput

0.691

High

890699

RGS4
Regulator of G-protein signaling 4

1

2

High-throughput

0.691

High

931843

EPHA5
Ephrin type-A receptor 5

1

17

High-throughput

0.691

High

1097188

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

High-throughput

0.691

High

250242

VINEX
Vinexin

3

20

Small-scale

0.689

High

248528

O10H3
Olfactory receptor 10H3

3

1

High-throughput

0.667

High

872284

SOX2
Transcription factor SOX-2

3

8

High-throughput

0.667

High

440056

LCK
Tyrosine-protein kinase Lck

1

18

Small-scale

0.647

High

533992

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

5

Small-scale

0.647

High

776951

PPM1A
Protein phosphatase 1A

1

11

Small-scale

0.647

High

1060773

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.647

High

1097235

FBX28
F-box only protein 28

4

1

High-throughput

0.643

High

878446

PAXI
Paxillin

3

14

High-throughput

0.633

High

253948

LPXN
Leupaxin

2

8

High-throughput

0.628

High

387832

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

7

High-throughput

0.628

High

427888

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.628

High

1097218

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

2

High-throughput

0.628

High

1097220

KIFA3
Kinesin-associated protein 3

2

5

High-throughput

0.628

High

371924

MYC
Myc proto-oncogene protein

2

5

Small-scale

0.619

High

297101

PAK3
Serine/threonine-protein kinase PAK 3

1

17

High-throughput

0.618

High

363214

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

375475

RASK
GTPase KRas

1

12

High-throughput

0.618

High

411854

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.618

High

440530

FYN
Tyrosine-protein kinase Fyn

1

18

Small-scale

0.618

High

463077

YES
Tyrosine-protein kinase Yes

1

18

Small-scale

0.618

High

463497

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

466232

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

541463

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.618

High

601267

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

648498

FGFR4
Fibroblast growth factor receptor 4

1

12

High-throughput

0.618

High

849157

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

891508

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.618

High

953421

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

959323

RAP1B
Ras-related protein Rap-1b

1

20

High-throughput

0.618

High

962008

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1015407

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1097196

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.618

High

1097199

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1097201

MK14
Mitogen-activated protein kinase 14

1

15

Small-scale

0.618

High

1097203

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

7

High-throughput

0.618

High

1097209

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1097225

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1097232

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1097233

TLR9
Toll-like receptor 9

1

1

Small-scale

0.618

High

1097241

ALK
ALK tyrosine kinase receptor

1

10

High-throughput

0.618

High

1097237

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

1033972

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.602

High

167507

TX1B3
Tax1-binding protein 3

2

13

High-throughput

0.601

High

85180

B7Z6G2
cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7

1

19

High-throughput

0.575

High

1097200

MYLK
Myosin light chain kinase, smooth muscle

1

3

Small-scale

0.575

High

1097243

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.575

High

1097222

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.561

High

936906

CASP7
Caspase-7

1

6

Small-scale

0.554

High

529730

TAU
Microtubule-associated protein tau

2

10

High-throughput

0.552

High

1097192

SRC8
Src substrate cortactin

2

17

Small-scale

0.552

High

1067259

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.541

High

279751

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.536

High

637101

VATC1
V-type proton ATPase subunit C 1

1

1

High-throughput

0.536

High

930873

HSP72
Heat shock-related 70 kDa protein 2

1

9

High-throughput

0.536

High

933002

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.536

High

937235

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

5

High-throughput

0.536

High

966267

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

991315

SUMO1
Small ubiquitin-related modifier 1

1

3

High-throughput

0.536

High

992158

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

1097197

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.536

High

1097198

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.536

High

1097212

SETX
Probable helicase senataxin

1

2

High-throughput

0.536

High

1097224

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

7

High-throughput

0.536

High

1097228

BUD13
BUD13 homolog

1

4

High-throughput

0.536

High

1097236

CARF
CDKN2A-interacting protein

1

1

High-throughput

0.536

High

1097217

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.528

High

320237

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.515

High

535007

BIP
Endoplasmic reticulum chaperone BiP

1

14

Small-scale

0.515

High

669889

MCM3
DNA replication licensing factor MCM3

1

6

High-throughput

0.515

High

773173

MYH10
Myosin-10

1

20

High-throughput

0.515

High

987604

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.515

High

1097230

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.515

High

1016332

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1097202

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

185652

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

422036

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

979592

H4
Histone H4

1

5

Small-scale

0.501

High

1097219

DOCK2
Dedicator of cytokinesis protein 2

1

2

Small-scale

0.501

High

1097239

ABI3
ABI gene family member 3

1

16

Small-scale

0.501

High

1097205

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.489

High

161808

RIOK3
Serine/threonine-protein kinase RIO3

1

3

High-throughput

0.481

High

130083

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.479

High

259887

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

345749

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

445541

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.479

High

452247

PDIA1
Protein disulfide-isomerase

1

2

High-throughput

0.479

High

456718

ANXA2
Annexin A2

1

7

High-throughput

0.479

High

556054

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

588596

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

606711

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

629826

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

636846

GSTM3
Glutathione S-transferase Mu 3

1

3

High-throughput

0.479

High

642838

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

659775

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.479

High

680861

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

681154

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

695352

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

697101

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

697867

CALR
Calreticulin

1

1

High-throughput

0.479

High

714080

PML
Protein PML

1

16

High-throughput

0.479

High

717297

PEBP1
Phosphatidylethanolamine-binding protein 1

1

3

High-throughput

0.479

High

768090

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

843527

HD
Huntingtin

1

4

Small-scale

0.479

High

862094

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

879037

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

932463

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.479

High

942593

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

967700

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

17

Small-scale

0.479

High

968283

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

17

Small-scale

0.479

High

978504

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

985452

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

1013752

RL24
Large ribosomal subunit protein eL24

1

2

High-throughput

0.479

High

1023766

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.479

High

1046989

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

High-throughput

0.479

High

1085535

FOXO1
Forkhead box protein O1

1

10

High-throughput

0.479

High

1094530

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.479

High

1096670

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

1097183

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

1097184

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.479

High

1097185

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

2

High-throughput

0.479

High

1097187

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.479

High

1097194

SEPT2
Septin-2

1

2

High-throughput

0.479

High

1097207

SPD2A
SH3 and PX domain-containing protein 2A

1

20

Small-scale

0.479

High

1097210

MOB3C
MOB kinase activator 3C

1

12

High-throughput

0.479

High

1097213

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1097214

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

Small-scale

0.479

High

1097215

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1097221

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1097223

OPTN
Optineurin

1

20

High-throughput

0.479

High

1097226

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

1097227

PSB7
Proteasome subunit beta type-7

1

3

High-throughput

0.479

High

1097240

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1097242

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

3

High-throughput

0.479

High

1097244

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

286194

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

362033

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

643469

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

666092

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

894538

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

1097204

FSCN1
Fascin

1

0

High-throughput

0.458

High

142333

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

330146

VENTX
Homeobox protein VENTX

1

9

High-throughput

0.445

High

767191

MERL
Merlin

1

6

Small-scale

0.445

High

840047

CASP3
Caspase-3

1

6

Small-scale

0.445

High

900608

GRAM
Granzyme M

1

4

Small-scale

0.445

High

1097208

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.445

High

1097234

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

105858

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

405194

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.437

High

717076

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.437

High

1097193

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.437

High

946993

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

886816

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1097186

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1097206

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1097216

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

377151

PRL
Prolactin

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025