Interactor 1: CAC1S (P07293)
Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Dihydropyridine receptor alpha-1S subunit) (DHPR) (Voltage-gated calcium channel subunit alpha Cav1.1)
Gene: CACNA1S

Interactor 2: RYR1 (P11716)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Species: Oryctolagus cuniculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 9525869
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ion_trans~Ion_trans, Ion_trans~RR_TM4-6
Common GO terms GO:0005245 - voltage-gated calcium channel activity
GO:0005516 - calmodulin binding
GO:0006936 - muscle contraction
GO:0044325 - transmembrane transporter binding
GO:0051209 - release of sequestered calcium ion into cytosol
and 2 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1873
Oc

1 5037
+ Mm
+ Hs
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Last updated: 15 Jul 2024