Protein: WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]

Gene: WRN
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q14191

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding
GO:0000723 - telomere maintenance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994162

DHX9
ATP-dependent RNA helicase A

2

20

Small-scale

0.799

High

867593

BLM
RecQ-like DNA helicase BLM

1

18

Small-scale

0.761

High

523746

XRCC6
X-ray repair cross-complementing protein 6

9

14

Small-scale

0.760

High

524923

XRCC5
X-ray repair cross-complementing protein 5

8

14

Small-scale

0.758

High

651182

RFA1
Replication protein A 70 kDa DNA-binding subunit

10

13

Small-scale

0.753

High

1050607

MIB1
E3 ubiquitin-protein ligase MIB1

1

7

Small-scale

0.747

High

1050597

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

15

Small-scale

0.724

High

552705

RFA2
Replication protein A 32 kDa subunit

5

13

Small-scale

0.717

High

764379

FEN1
Flap endonuclease 1

4

2

Small-scale

0.717

High

720443

RFA3
Replication protein A 14 kDa subunit

5

8

Small-scale

0.709

High

517253

PCNA
Proliferating cell nuclear antigen

4

5

Small-scale

0.683

High

386720

P53
Cellular tumor antigen p53

3

6

Small-scale

0.676

High

1050606

SKAP1
Src kinase-associated phosphoprotein 1

3

17

High-throughput

0.667

High

749486

BRCA1
Breast cancer type 1 susceptibility protein

3

17

Small-scale

0.664

High

1050617

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

7

Small-scale

0.659

High

802434

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.647

High

1050622

BARD1
BRCA1-associated RING domain protein 1

1

7

Small-scale

0.647

High

1050637

RA54B
DNA repair and recombination protein RAD54B

1

20

Small-scale

0.647

High

455429

PARP1
Poly [ADP-ribose] polymerase 1

2

11

Small-scale

0.646

High

1050601

TERF2
Telomeric repeat-binding factor 2

2

4

Small-scale

0.641

High

988074

RAD51
DNA repair protein RAD51 homolog 1

2

14

Small-scale

0.634

High

1038111

ATR
Serine/threonine-protein kinase ATR

3

11

Small-scale

0.631

High

795501

RAD52
DNA repair protein RAD52 homolog

2

0

Small-scale

0.628

High

169848

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

Small-scale

0.618

High

328842

TOP3B
DNA topoisomerase 3-beta-1

1

11

High-throughput

0.618

High

757609

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.618

High

877269

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

20

High-throughput

0.618

High

917252

H4
Histone H4

1

8

High-throughput

0.618

High

944777

RED1
Double-stranded RNA-specific editase 1

1

19

High-throughput

0.618

High

1019737

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.618

High

1050598

DHX8
ATP-dependent RNA helicase DHX8

1

18

High-throughput

0.618

High

1050634

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.618

High

944235

PRKDC
DNA-dependent protein kinase catalytic subunit

2

10

Small-scale

0.613

High

874921

TERA
Transitional endoplasmic reticulum ATPase

2

7

Small-scale

0.601

High

246225

NBN
Nibrin

2

4

Small-scale

0.584

High

555458

H2AX
Histone H2AX

1

8

Small-scale

0.578

High

962779

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.578

High

1050619

WRIP1
ATPase WRNIP1

1

6

Small-scale

0.573

High

369589

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

790776

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

Small-scale

0.561

High

1024460

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.561

High

238270

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.537

High

1050621

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

1031522

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.536

High

364888

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

734511

ARL3
ADP-ribosylation factor-like protein 3

1

5

High-throughput

0.536

High

800373

CBX5
Chromobox protein homolog 5

1

11

Small-scale

0.536

High

1050614

CBP
CREB-binding protein

1

11

Small-scale

0.536

High

1050633

DPOLL
DNA polymerase lambda

1

1

High-throughput

0.536

High

1050610

WDR48
WD repeat-containing protein 48

1

20

High-throughput

0.515

High

1050611

CTBL1
Beta-catenin-like protein 1

1

2

High-throughput

0.515

High

1050618

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1050623

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.513

High

1050624

PAXX
Protein PAXX

1

0

High-throughput

0.513

High

417823

DPOLB
DNA polymerase beta

1

1

Small-scale

0.501

High

203685

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.500

High

785913

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

6

Small-scale

0.500

High

1050630

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

3

High-throughput

0.489

High

902579

SUMO2
Small ubiquitin-related modifier 2

1

10

Small-scale

0.481

High

928094

SUMO1
Small ubiquitin-related modifier 1

1

10

Small-scale

0.481

High

1050631

POLK
DNA polymerase kappa

1

0

Small-scale

0.480

High

177889

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

296305

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

10

Small-scale

0.479

High

319835

HERC2
E3 ubiquitin-protein ligase HERC2

1

14

Small-scale

0.479

High

374221

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

384826

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

475747

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

668676

PML
Protein PML

1

20

Small-scale

0.479

High

799101

NKX21
Homeobox protein Nkx-2.1

1

7

High-throughput

0.479

High

818035

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.479

High

823998

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

17

High-throughput

0.479

High

894001

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

922166

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

952328

H33
Histone H3.3

1

15

High-throughput

0.479

High

959415

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1014119

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

5

High-throughput

0.479

High

1038369

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.479

High

1041554

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1050600

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1050604

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

Small-scale

0.479

High

1050605

SHLD2
Shieldin complex subunit 2

1

2

High-throughput

0.479

High

1050608

SLX4
Structure-specific endonuclease subunit SLX4

1

14

High-throughput

0.479

High

1050609

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1050612

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1050613

HDAC2
Histone deacetylase 2

1

17

Small-scale

0.479

High

1050615

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

16

High-throughput

0.479

High

1050616

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1050620

CDC5L
Cell division cycle 5-like protein

1

7

Small-scale

0.479

High

1050625

MOV10
Helicase MOV-10

1

9

High-throughput

0.479

High

1050627

ARL8B
ADP-ribosylation factor-like protein 8B

1

3

High-throughput

0.479

High

1050628

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

4

Small-scale

0.479

High

1050632

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

1050636

SP16H
FACT complex subunit SPT16

1

3

High-throughput

0.479

High

429890

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

135249

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

1050629

GRHL1
Grainyhead-like protein 1 homolog

1

5

High-throughput

0.445

High

1050603

LRC31
Leucine-rich repeat-containing protein 31

1

6

High-throughput

0.437

High

1050626

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.426

High

1050599

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

Small-scale

0.408

High

1050602

K0930
Uncharacterized protein KIAA0930

3

0

High-throughput

0.347

High

1050635

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024