Protein: H2A1H
Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)

Gene: H2A1H, H2AC12
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q96KK5

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0030527 - structural constituent of chromatin
GO:0031507 - heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1258916

H32
Histone H3.2

3

20

High-throughput

0.827

High

595559

H15
Histone H1.5

2

20

High-throughput

0.776

High

596300

H12
Histone H1.2

2

20

High-throughput

0.776

High

943406

H2BFS
Histone H2B type F-S

2

20

High-throughput

0.776

High

1037317

H11
Histone H1.1

2

20

High-throughput

0.776

High

1162003

H31T
Histone H3.1t

2

20

High-throughput

0.776

High

502481

H2A1
Histone H2A type 1

2

19

High-throughput

0.754

High

980152

H4
Histone H4

2

15

High-throughput

0.754

High

1017120

H33
Histone H3.3

2

20

High-throughput

0.754

High

455845

H10
Histone H1.0

1

5

High-throughput

0.665

High

987449

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

17

High-throughput

0.665

High

1210505

HP1B3
Heterochromatin protein 1-binding protein 3

1

2

High-throughput

0.665

High

1363600

H1X
Histone H1.10

1

4

High-throughput

0.665

High

1372268

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

1396100

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

10

High-throughput

0.665

High

256953

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

277779

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.618

High

419138

H2A1B
Histone H2A type 1-B/E

1

19

High-throughput

0.618

High

449773

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

521862

H14
Histone H1.4

1

20

High-throughput

0.618

High

595846

H13
Histone H1.3

1

20

High-throughput

0.618

High

634054

H2A1D
Histone H2A type 1-D

1

19

High-throughput

0.618

High

649394

H1T
Histone H1t

1

20

High-throughput

0.618

High

659932

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.618

High

754941

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

888257

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

946857

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.618

High

981015

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998689

H31
Histone H3.1

1

20

High-throughput

0.618

High

1088507

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.618

High

1132896

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1145508

RBBP5
Retinoblastoma-binding protein 5

1

8

High-throughput

0.618

High

1155667

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

High-throughput

0.618

High

1162868

H2A2C
Histone H2A type 2-C

1

19

High-throughput

0.618

High

1163140

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.618

High

1208874

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.618

High

1232711

H2A2A
Histone H2A type 2-A

1

19

High-throughput

0.618

High

1239466

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1272811

H2A3
Histone H2A type 3

1

19

High-throughput

0.618

High

1307298

H2A2B
Histone H2A type 2-B

1

19

High-throughput

0.618

High

1323956

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.618

High

1329813

SIR6
NAD-dependent protein deacylase sirtuin-6

1

10

High-throughput

0.618

High

1372235

H2A1C
Histone H2A type 1-C

1

19

High-throughput

0.618

High

1396081

H2A1A
Histone H2A type 1-A

1

19

High-throughput

0.618

High

1396086

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.618

High

1396087

H2A1J
Histone H2A type 1-J

1

20

High-throughput

0.618

High

1396089

H2AJ
Histone H2A.J

1

19

High-throughput

0.618

High

1396101

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.618

High

436716

KPCB
Protein kinase C beta type

2

10

High-throughput

0.571

High

702366

ELK4
ETS domain-containing protein Elk-4

2

9

High-throughput

0.571

High

187159

PPM1G
Protein phosphatase 1G

1

11

High-throughput

0.554

High

651407

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.553

High

1220738

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.553

High

530230

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.536

High

1367035

ESR2
Estrogen receptor beta

1

10

Small-scale

0.536

High

1396096

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

5

High-throughput

0.536

High

130880

RFXAP
Regulatory factor X-associated protein

1

1

High-throughput

0.515

High

424449

HMGN1
Non-histone chromosomal protein HMG-14

1

4

High-throughput

0.515

High

426557

HMGN2
Non-histone chromosomal protein HMG-17

1

10

High-throughput

0.515

High

601809

HMGA1
High mobility group protein HMG-I/HMG-Y

1

6

High-throughput

0.515

High

996293

EF1A1
Elongation factor 1-alpha 1

1

4

High-throughput

0.515

High

1270323

SPT6H
Transcription elongation factor SPT6

1

6

High-throughput

0.515

High

1330768

ANR31
Ankyrin repeat domain-containing protein 31

1

14

High-throughput

0.515

High

1361895

TITIN
Titin

1

7

High-throughput

0.515

High

464284

FUMH
Fumarate hydratase, mitochondrial

1

0

Small-scale

0.513

High

800053

COIL
Coilin

1

0

High-throughput

0.493

High

1396083

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.493

High

909139

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.489

High

248044

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

260311

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

325050

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

482527

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

667987

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

756016

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

986637

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

995767

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.479

High

1115362

CUL4B
Cullin-4B

1

14

High-throughput

0.479

High

1120290

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

1194286

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1271796

MEPCE
7SK snRNA methylphosphate capping enzyme

1

12

High-throughput

0.479

High

1281587

SLN11
Schlafen family member 11

1

6

High-throughput

0.479

High

1334788

SERB1
SERPINE1 mRNA-binding protein 1

1

11

High-throughput

0.479

High

1396080

CI072
Guanine nucleotide exchange factor C9orf72

1

10

High-throughput

0.479

High

1396082

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

Small-scale

0.479

High

1396085

NECD
Necdin

1

6

High-throughput

0.479

High

1396090

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.479

High

1396091

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

1396092

TRI55
Tripartite motif-containing protein 55

1

14

High-throughput

0.479

High

1396098

BRD7
Bromodomain-containing protein 7

1

20

Small-scale

0.479

High

1396102

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

1396103

LOXL2
Lysyl oxidase homolog 2

1

4

High-throughput

0.479

High

1291403

TRXR3
Thioredoxin reductase 3

1

1

High-throughput

0.470

High

1352153

DYH5
Dynein axonemal heavy chain 5

1

3

High-throughput

0.470

High

1370944

PRG4
Proteoglycan 4

1

7

High-throughput

0.470

High

1396093

TANC1
Protein TANC1

1

3

High-throughput

0.470

High

609888

IBP3
Insulin-like growth factor-binding protein 3

1

0

Small-scale

0.458

High

785854

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1385227

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1396094

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1396097

SHCAF
SIN3-HDAC complex-associated factor

1

0

Small-scale

0.458

High

911654

NCBP2
Nuclear cap-binding protein subunit 2

1

6

High-throughput

0.445

High

1396095

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.445

High

353507

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

1047472

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.437

High

1137944

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1255102

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1360116

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

4

High-throughput

0.437

High

1396084

RUFY1
RUN and FYVE domain-containing protein 1

1

6

High-throughput

0.437

High

1198636

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1193711

C2CD3
C2 domain-containing protein 3

1

0

High-throughput

0.269

Low

1228184

OLM2B
Olfactomedin-like protein 2B

1

0

High-throughput

0.269

Low

1396088

CF300
Cilia- and flagella-associated protein 300

1

0

High-throughput

0.269

Low

378166

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

521413

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.249

Low

1218634

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1396099

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1340227

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025