HitPredict

Interactor 1: FES (P07332)
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Gene: FES

Interactor 2: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	25852190, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 2871
+	Hs
		411581 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		433558 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		411983 FYN_HUMAN (399-816): 2.27e-151: 455: 32.96		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		426959 FES_HUMAN (1-822): 0: 838: 100.00		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		411707 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		GOGA4_HUMAN (1137-2522): 1.45e-40: 168: 9.60
+	Hs
		337470 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67
+	Hs
		411715 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67
+	Hs
		433753 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67
+	Hs
		412330 FYN_HUMAN (399-816): 2.27e-151: 455: 32.96		AKAP9_HUMAN (1336-2427): 2.28e-27: 125: 8.91
+	Hs
		411682 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		DYST_HUMAN (91-2218): 3.51e-25: 118: 10.10
+	Hs
		433710 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		DYST_HUMAN (91-2218): 3.51e-25: 118: 10.10
+	Hs
		411724 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		GOGB1_HUMAN (1530-2529): 4.77e-20: 101: 9.08
+	Hs
		523231 SRC_HUMAN (323-816): 2.27e-147: 445: 30.62		MYH4_HUMAN (46-713): 1.54e-15: 86.1: 9.64
+	Hs
		411676 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93
+	Hs
		411889 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		MACF1_HUMAN (1987-2820): 9.45e-10: 67.2: 12.38
+	Hs
		433700 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93
+	Hs
		434078 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		MACF1_HUMAN (1987-2820): 9.45e-10: 67.2: 12.38