Protein: GPC4
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]

Gene: GPC4
Organism: Homo sapiens
Interactions: 101
UniProt ID: O75487

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
GO:0009966 - regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

283729

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

4

0

High-throughput

0.846

High

283683

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

Small-scale

0.724

High

283709

CAMKV
CaM kinase-like vesicle-associated protein

4

3

High-throughput

0.697

High

283660

CEAM8
Cell adhesion molecule CEACAM8

1

3

High-throughput

0.691

High

283661

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.667

High

193476

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

3

High-throughput

0.650

High

283647

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

8

Small-scale

0.647

High

283656

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

8

Small-scale

0.647

High

283663

SRP14
Signal recognition particle 14 kDa protein

2

1

High-throughput

0.628

High

283706

MINK1
Misshapen-like kinase 1

2

1

High-throughput

0.611

High

283704

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

2

13

High-throughput

0.601

High

283721

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

262190

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.575

High

283682

SG2A2
Mammaglobin-A

2

2

High-throughput

0.574

High

283685

SPCS2
Signal peptidase complex subunit 2

2

2

High-throughput

0.574

High

283692

MPPE1
Metallophosphoesterase 1

2

1

High-throughput

0.574

High

283694

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.558

High

283665

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

7

High-throughput

0.549

High

283703

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

2

13

High-throughput

0.549

High

283642

FGF1
Fibroblast growth factor 1

1

8

High-throughput

0.536

High

283643

HEPS
Serine protease hepsin

1

11

High-throughput

0.536

High

283649

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

283659

CALX
Calnexin

1

4

High-throughput

0.536

High

283684

SQSTM
Sequestosome-1

1

1

High-throughput

0.536

High

283689

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.536

High

283716

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

1

1

High-throughput

0.536

High

283718

TMPSD
Transmembrane protease serine 13

1

12

High-throughput

0.536

High

283724

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

1

High-throughput

0.536

High

283728

ST14
Suppressor of tumorigenicity 14 protein

1

11

High-throughput

0.536

High

283651

SRF
Serum response factor

1

0

High-throughput

0.513

High

283654

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

283662

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

0

High-throughput

0.513

High

283670

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

283672

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

283687

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

283646

FGF2
Fibroblast growth factor 2

1

8

Small-scale

0.501

High

283676

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

283726

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.500

High

283637

SG2A1
Mammaglobin-B

1

2

High-throughput

0.489

High

283644

FGF4
Fibroblast growth factor 4

1

8

High-throughput

0.489

High

283671

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.489

High

283730

SPCS1
Signal peptidase complex subunit 1

1

1

High-throughput

0.489

High

283657

CCNC
Cyclin-C

1

0

High-throughput

0.486

High

283714

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.486

High

283717

AKAP9
A-kinase anchor protein 9

1

4

High-throughput

0.481

High

142757

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

188747

TMPS2
Transmembrane protease serine 2

1

12

High-throughput

0.479

High

256718

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

283645

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.479

High

283666

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

283668

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

283673

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

283678

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

283679

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.479

High

283688

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

283690

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

283713

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.479

High

283725

CLC4E
C-type lectin domain family 4 member E

1

6

High-throughput

0.479

High

283640

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

283641

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

283653

CD36
Platelet glycoprotein 4

1

0

Small-scale

0.458

High

283658

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

283664

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

283681

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

283691

MIDN
Midnolin

1

0

High-throughput

0.458

High

283698

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

283705

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

283722

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

215965

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.445

High

283638

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

283650

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.445

High

283652

FOSL2
Fos-related antigen 2

1

2

High-throughput

0.445

High

283655

SYT1
Synaptotagmin-1

1

3

High-throughput

0.445

High

283667

S19A1
Reduced folate transporter

1

1

High-throughput

0.445

High

283669

P2RY1
P2Y purinoceptor 1

1

7

High-throughput

0.445

High

283675

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

283696

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

283699

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.445

High

283700

ZNT10
Calcium/manganese antiporter SLC30A10

1

1

High-throughput

0.445

High

283707

SYT2
Synaptotagmin-2

1

3

High-throughput

0.445

High

283710

MOT10
Monocarboxylate transporter 10

1

4

High-throughput

0.445

High

283715

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

2

High-throughput

0.445

High

283727

FLVC2
Choline/ethanolamine transporter FLVCR2

1

1

High-throughput

0.445

High

190104

TNC18
Trinucleotide repeat-containing gene 18 protein

1

1

High-throughput

0.437

High

283686

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

283720

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

283648

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

283701

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.426

High

283719

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

283723

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.426

High

283639

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

283674

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

3

High-throughput

0.407

High

283680

ECHP
Peroxisomal bifunctional enzyme

1

7

High-throughput

0.407

High

283695

ZNT6
Zinc transporter 6

1

1

High-throughput

0.407

High

283702

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

14

High-throughput

0.407

High

283711

CA054
Uncharacterized protein C1orf54

2

0

High-throughput

0.313

High

283677

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.279

Low

283697

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

283712

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

0

High-throughput

0.279

Low

283693

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

283708

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025