HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: ARRD1 (Q8N5I2)
Arrestin domain-containing protein 1 (Alpha-arrestin 1)
Gene: ARRDC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	21982743, 24561123
Identification Methods	affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 433
+	Hs
		429100 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		429087 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		ARRD4_HUMAN (2-361): 1.4e-82: 261: 24.07
+	Hs
		428933 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Rn
		663954 Q8VBU7_RAT (1-413): 4.67e-118: 351: 87.56		ARRB2_RAT (22-320): 8.28e-69: 225: 16.29
+	Hs
		534048 ADRB3_HUMAN (5-336): 4.35e-70: 228: 46.57		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		441648 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Hs
		441649 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		ARRB1_HUMAN (22-339): 5.08e-70: 229: 15.29
+	Hs
		656989 5HT2A_HUMAN (10-345): 3.35e-68: 225: 25.90		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Hs
		208441 OX1R_HUMAN (50-387): 2.31e-68: 224: 22.16		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Hs
		208444 OX1R_HUMAN (50-387): 2.31e-68: 224: 22.16		ARRB1_HUMAN (22-339): 5.08e-70: 229: 15.29