Protein: RLA4
Large ribosomal subunit protein P2B (P2B) (60S acidic ribosomal protein P2-beta) (L12eIA) (L45) (YL44C) (YP2beta) (YPA1)

Gene: RLA4, RPP2B
Organism: Saccharomyces cerevisiae S288C
Interactions: 192
UniProt ID: P02400

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0002181 - cytoplasmic translation
GO:0002182 - cytoplasmic translational elongation
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

383036

RLA1
Large ribosomal subunit protein P1A

8

8

Small-scale

0.961

High

383035

RLA0
Large ribosomal subunit protein uL10

5

3

Small-scale

0.916

High

383037

RLA2
Large ribosomal subunit protein P2A

5

4

Small-scale

0.904

High

383068

RLA3
Large ribosomal subunit protein P1B

5

8

Small-scale

0.901

High

383028

RLA4
Large ribosomal subunit protein P2B

2

4

Small-scale

0.743

High

383030

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.640

High

383188

GCN5
Histone acetyltransferase GCN5

2

1

High-throughput

0.628

High

383170

BRE5
UBP3-associated protein BRE5

2

3

High-throughput

0.611

High

383080

CSK22
Casein kinase II subunit alpha'

2

2

Small-scale

0.602

High

383093

RL16A
Large ribosomal subunit protein uL13A

2

4

High-throughput

0.584

High

383204

TMA46
Translation machinery-associated protein 46

2

2

High-throughput

0.584

High

383075

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.571

High

383172

JJJ1
J protein JJJ1

2

6

High-throughput

0.571

High

383089

PWP2
Periodic tryptophan protein 2

2

1

High-throughput

0.567

High

383126

SEC31
Protein transport protein SEC31

2

2

High-throughput

0.567

High

383208

MAK21
Ribosome biogenesis protein MAK21

2

1

High-throughput

0.567

High

383198

RQC1
Ribosome quality control complex subunit 1

2

1

Small-scale

0.558

High

383119

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

2

1

High-throughput

0.537

High

383159

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

1

High-throughput

0.536

High

383164

SGF73
SAGA complex subunit SGF73

1

1

High-throughput

0.536

High

383179

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

383048

KAPC
cAMP-dependent protein kinase type 3

1

1

High-throughput

0.501

High

383050

KIN28
Serine/threonine-protein kinase KIN28

1

2

High-throughput

0.501

High

383076

CSK21
Casein kinase II subunit alpha

1

4

Small-scale

0.501

High

383106

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.494

High

383052

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.489

High

383086

SGF29
SAGA complex subunit SGF29

1

1

High-throughput

0.489

High

383110

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.489

High

383117

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

4

High-throughput

0.489

High

383157

SPT20
SAGA complex subunit SPT20

1

1

High-throughput

0.489

High

383189

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

1

High-throughput

0.489

High

383197

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

High-throughput

0.489

High

383216

SUS1
SAGA complex subunit SUS1

1

2

High-throughput

0.489

High

154090

RL36B
Large ribosomal subunit protein eL36B

1

4

High-throughput

0.479

High

383029

RL28
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

383032

RL24A
Large ribosomal subunit protein eL24A

1

3

High-throughput

0.479

High

383033

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

383034

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

383038

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.479

High

383039

RL9A
Large ribosomal subunit protein uL6A

1

2

High-throughput

0.479

High

383040

RL6B
Large ribosomal subunit protein eL6B

1

3

High-throughput

0.479

High

383041

RL17A
Large ribosomal subunit protein uL22A

1

3

High-throughput

0.479

High

383042

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

383043

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

383044

RL36A
Large ribosomal subunit protein eL36A

1

4

High-throughput

0.479

High

383046

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.479

High

383047

RL22A
Large ribosomal subunit protein eL22A

1

3

High-throughput

0.479

High

383051

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

3

High-throughput

0.479

High

383053

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

383054

RL11A
Large ribosomal subunit protein uL5A

1

3

High-throughput

0.479

High

383055

RL27A
Large ribosomal subunit protein eL27A

1

2

High-throughput

0.479

High

383056

RL27B
Large ribosomal subunit protein eL27B

1

2

High-throughput

0.479

High

383057

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

383058

RL31B
Large ribosomal subunit protein eL31B

1

2

High-throughput

0.479

High

383059

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.479

High

383060

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.479

High

383062

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.479

High

383063

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.479

High

383066

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

383067

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.479

High

383069

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.479

High

383070

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.479

High

383071

PDR1
Transcription factor PDR1

1

1

High-throughput

0.479

High

383073

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.479

High

383074

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

383078

RL8A
Large ribosomal subunit protein eL8A

1

4

High-throughput

0.479

High

383081

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.479

High

383082

RL24B
Large ribosomal subunit protein eL24B

1

3

High-throughput

0.479

High

383084

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

383090

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

383092

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

383094

RL16B
Large ribosomal subunit protein uL13B

1

4

High-throughput

0.479

High

383099

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.479

High

383100

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

383103

ZUO1
Zuotin

1

4

High-throughput

0.479

High

383107

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

383112

RL14A
Large ribosomal subunit protein eL14A

1

4

High-throughput

0.479

High

383115

RL32
Large ribosomal subunit protein eL32

1

3

High-throughput

0.479

High

383118

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

3

High-throughput

0.479

High

383121

RL14B
Large ribosomal subunit protein eL14B

1

4

High-throughput

0.479

High

383123

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.479

High

383128

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

383130

RBG1
Ribosome-interacting GTPase 1

1

2

High-throughput

0.479

High

383131

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

383135

RL13B
Large ribosomal subunit protein eL13B

1

3

High-throughput

0.479

High

383140

RL34B
Large ribosomal subunit protein eL34B

1

3

High-throughput

0.479

High

383143

RLP7
Ribosome biogenesis protein RLP7

1

4

High-throughput

0.479

High

383144

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

383147

RL17B
Large ribosomal subunit protein uL22B

1

3

High-throughput

0.479

High

383152

RL37A
Large ribosomal subunit protein eL37A

1

3

High-throughput

0.479

High

383153

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.479

High

383154

RL4B
Large ribosomal subunit protein uL4B

1

3

High-throughput

0.479

High

383158

RL37B
Large ribosomal subunit protein eL37B

1

3

High-throughput

0.479

High

383165

RL26B
Large ribosomal subunit protein uL24B

1

3

High-throughput

0.479

High

383176

RL22B
Large ribosomal subunit protein eL22B

1

3

High-throughput

0.479

High

383178

RL34A
Large ribosomal subunit protein eL34A

1

3

High-throughput

0.479

High

383180

RL6A
Large ribosomal subunit protein eL6A

1

3

High-throughput

0.479

High

383184

RL21A
Large ribosomal subunit protein eL21A

1

3

High-throughput

0.479

High

383190

HMO1
High mobility group protein 1

1

4

High-throughput

0.479

High

383192

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

383196

LTN1
E3 ubiquitin-protein ligase listerin

1

1

Small-scale

0.479

High

383209

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.479

High

383212

RL21B
Large ribosomal subunit protein eL21B

1

3

High-throughput

0.479

High

383213

RL13A
Large ribosomal subunit protein eL13A

1

3

High-throughput

0.479

High

383215

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.479

High

383045

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

383061

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.458

High

383064

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

383065

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

383134

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.458

High

383160

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

383163

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.458

High

383201

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

383206

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.458

High

383085

KCC4
Probable serine/threonine-protein kinase KCC4

1

2

High-throughput

0.457

High

383095

CDC15
Cell division control protein 15

1

2

High-throughput

0.457

High

383149

IKS1
Probable serine/threonine-protein kinase IKS1

1

4

High-throughput

0.457

High

383210

PKH2
Serine/threonine-protein kinase PKH2

1

2

High-throughput

0.457

High

383104

RPD3
Histone deacetylase RPD3

1

3

Small-scale

0.457

High

383162

SNT2
E3 ubiquitin-protein ligase SNT2

1

1

Small-scale

0.457

High

383141

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

383183

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

364201

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.437

High

383049

SC160
Protein SCP160

1

3

High-throughput

0.437

High

383072

ACOX
Acyl-coenzyme A oxidase

1

2

High-throughput

0.437

High

383077

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

383083

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

383087

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

383088

SYP1
Suppressor of yeast profilin deletion

1

1

High-throughput

0.437

High

383091

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

383096

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

383097

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

383109

IXR1
Intrastrand cross-link recognition protein

1

4

Small-scale

0.437

High

383113

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.437

High

383114

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.437

High

383120

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.437

High

383127

STM1
Suppressor protein STM1

1

1

High-throughput

0.437

High

383129

ECM1
Shuttling pre-60S factor ECM1

1

1

High-throughput

0.437

High

383132

NOC2
Nucleolar complex protein 2

1

1

Small-scale

0.437

High

383138

TM108
Protein TMA108

1

2

High-throughput

0.437

High

383142

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

383145

ELP2
Elongator complex protein 2

1

3

High-throughput

0.437

High

383146

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

383150

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

383151

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

383155

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.437

High

383161

VID30
GID complex subunit 1

1

1

High-throughput

0.437

High

383166

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

383167

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.437

High

383168

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

383169

H1
Histone H1

1

1

High-throughput

0.437

High

383171

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.437

High

383173

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

383175

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

383182

ABF2
ARS-binding factor 2, mitochondrial

1

4

High-throughput

0.437

High

383187

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

383191

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

383194

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.437

High

383200

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

383203

SGO1
Shugoshin

1

1

High-throughput

0.437

High

383211

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.437

High

383214

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.437

High

383156

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

383181

ADA2
SAGA complex subunit ADA2

1

1

High-throughput

0.407

High

383205

HFI1
SAGA complex subunit HFI1

1

1

High-throughput

0.407

High

383079

SKI3
Superkiller protein 3

1

0

High-throughput

0.279

Low

383193

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.279

Low

383116

SSDH
Succinate-semialdehyde dehydrogenase [NADP(+)]

1

0

High-throughput

0.265

Low

383031

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

383098

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

383101

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

383102

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

383105

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.249

Low

383111

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

383122

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

383124

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.249

Low

383125

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.249

Low

383133

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

0

High-throughput

0.249

Low

383137

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

383174

FAP1
FKBP12-associated protein 1

1

0

High-throughput

0.249

Low

383185

ELP3
Elongator complex protein 3

1

0

High-throughput

0.249

Low

383186

ESP1
Separin

1

0

High-throughput

0.249

Low

383195

VBA4
Vacuolar basic amino acid transporter 4

1

0

High-throughput

0.249

Low

383199

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.249

Low

383202

NOP6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

383207

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.249

Low

383148

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

383177

ACT
Actin

1

0

Small-scale

0.238

Low

383108

YME2
Mitochondrial escape protein 2

1

0

High-throughput

0.232

Low

383136

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

383139

ICE2
Protein ICE2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025