HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27684187, 22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1367
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (14-1310): 0: 1170: 55.26
+	Hs
		437855 HS90B_HUMAN (19-732): 0: 1059: 86.13		INSRR_HUMAN (14-1310): 0: 1170: 55.26
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (666-1311): 0: 564: 24.96
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93
+	Hs
		432361 HS90A_HUMAN (1-732): 0: 1087: 100.00		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		431901 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95
+	Hs
		384111 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96
+	Hs
		431568 HS90A_HUMAN (1-732): 0: 1087: 100.00		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		431892 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		384122 HS90B_HUMAN (19-732): 0: 1059: 86.13		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96
+	Hs
		437838 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Rn
		948940 HS90A_RAT (1-732): 0: 1085: 97.95		Q8K3F9_RAT (15-308): 1.32e-28: 127: 20.53
+	Hs
		431532 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (484-650): 8.3e-11: 69: 17.75