HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: LIMK2 (P53671)
LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)
Gene: LIMK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22939624, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 638
+	Hs
		438023 HS90B_HUMAN (19-732): 0: 1059: 86.13		LIMK2_HUMAN (1-638): 0: 577: 100.00
+	Hs
		431683 HS90A_HUMAN (1-732): 0: 1087: 100.00		LIMK1_HUMAN (6-638): 1.03e-170: 503: 52.73
+	Hs
		438022 HS90B_HUMAN (19-732): 0: 1059: 86.13		LIMK1_HUMAN (6-638): 1.03e-170: 503: 52.73
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (7-632): 4.77e-154: 471: 17.54
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (7-629): 2.44e-151: 463: 18.27
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (7-631): 3.48e-149: 458: 18.13
+	Hs
		438028 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHB1_HUMAN (7-632): 4.77e-154: 471: 17.54
+	Hs
		438029 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA4_HUMAN (7-631): 3.48e-149: 458: 18.13
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (9-636): 4.26e-137: 426: 18.52
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (5-636): 6.05e-133: 416: 19.06
+	Hs
		437918 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA2_HUMAN (9-636): 4.26e-137: 426: 18.52
+	Hs
		437892 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA1_HUMAN (5-636): 6.05e-133: 416: 19.06
+	Hs
		538167 ENPL_HUMAN (14-701): 0: 898: 46.78		LIMK2_HUMAN (1-638): 0: 577: 100.00
+	Hs
		431880 HS90A_HUMAN (1-732): 0: 1087: 100.00		TESK1_HUMAN (313-637): 6.25e-96: 309: 40.85
+	Hs
		438195 HS90B_HUMAN (19-732): 0: 1059: 86.13		TESK1_HUMAN (313-637): 6.25e-96: 309: 40.85
+	Hs
		432182 HS90A_HUMAN (1-732): 0: 1087: 100.00		TESK2_HUMAN (335-610): 2.37e-60: 213: 40.86
+	Hs
		538261 ENPL_HUMAN (14-701): 0: 898: 46.78		EPHAA_HUMAN (10-632): 5.95e-118: 377: 17.71
+	Hs
		438454 HS90B_HUMAN (19-732): 0: 1059: 86.13		TESK2_HUMAN (335-610): 2.37e-60: 213: 40.86
+	Hs
		431507 HS90A_HUMAN (1-732): 0: 1087: 100.00		FER_HUMAN (330-598): 2.19e-29: 126: 31.73
+	Hs
		437867 HS90B_HUMAN (19-732): 0: 1059: 86.13		FER_HUMAN (330-598): 2.19e-29: 126: 31.73