Protein: MMP2
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]

Gene: MMP2
Organism: Homo sapiens
Interactions: 67
UniProt ID: P08253

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001541 - ovarian follicle development
GO:0001542 - ovulation from ovarian follicle
GO:0001553 - luteinization
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

469658

TIMP2
Metalloproteinase inhibitor 2

11

20

Small-scale

0.977

High

388921

FINC
Fibronectin

4

12

Small-scale

0.892

High

469666

TIMP3
Metalloproteinase inhibitor 3

3

20

Small-scale

0.866

High

469695

TIMP4
Metalloproteinase inhibitor 4

3

20

Small-scale

0.834

High

469681

COL12
Collectin-12

2

20

High-throughput

0.811

High

369992

TIMP1
Metalloproteinase inhibitor 1

2

20

Small-scale

0.789

High

469662

CO5A1

4

20

Small-scale

0.693

High

469667

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

4

20

Small-scale

0.687

High

384297

CO4A1

3

20

High-throughput

0.662

High

469654

CO4A2

3

20

High-throughput

0.662

High

469656

CO6A1

3

18

High-throughput

0.662

High

469657

CO6A2

3

20

High-throughput

0.662

High

469694

COCA1

3

20

High-throughput

0.662

High

421337

A4
Amyloid-beta precursor protein

3

8

Small-scale

0.650

High

469692

PGCB
Brevican core protein

1

13

Small-scale

0.647

High

384231

CO2A1
Collagen alpha-1(II) chain

2

20

High-throughput

0.628

High

469673

COEA1
Collagen alpha-1(XIV) chain

2

20

High-throughput

0.628

High

469680

H2A2C
Histone H2A type 2-C

2

2

High-throughput

0.628

High

469691

EDA
Ectodysplasin-A

2

20

High-throughput

0.628

High

469672

REL
Proto-oncogene c-Rel

2

3

High-throughput

0.606

High

469693

KLH15
Kelch-like protein 15

2

0

High-throughput

0.602

High

469670

CCL7
C-C motif chemokine 7

1

5

Small-scale

0.586

High

447959

ITAV
Integrin alpha-V

2

11

Small-scale

0.584

High

469689

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

4

Small-scale

0.568

High

464401

TSP1
Thrombospondin-1

1

8

Small-scale

0.552

High

469665

TSP2
Thrombospondin-2

1

9

Small-scale

0.552

High

469661

CAN3
Calpain-3

1

3

High-throughput

0.541

High

354505

PAK4
Serine/threonine-protein kinase PAK 4

1

0

Small-scale

0.537

High

251846

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

2

High-throughput

0.536

High

275865

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

2

High-throughput

0.536

High

469677

CO4A6

1

20

High-throughput

0.536

High

469686

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

461048

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.515

High

469668

MTR1A
Melatonin receptor type 1A

1

5

High-throughput

0.508

High

469669

MTR1B
Melatonin receptor type 1B

1

5

High-throughput

0.508

High

303058

CCN5
CCN family member 5

1

4

Small-scale

0.501

High

369590

A2MG
Alpha-2-macroglobulin

1

4

Small-scale

0.501

High

376676

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

7

Small-scale

0.501

High

384090

CO1A1
Collagen alpha-1(I) chain

1

20

Small-scale

0.501

High

465926

CO1A2
Collagen alpha-2(I) chain

1

20

Small-scale

0.501

High

469660

PZP
Pregnancy zone protein

1

4

Small-scale

0.501

High

469664

LYOX
Protein-lysine 6-oxidase

1

5

Small-scale

0.501

High

469688

GT252
Procollagen galactosyltransferase 2

1

2

High-throughput

0.489

High

469696

OSB10
Oxysterol-binding protein-related protein 10

1

1

High-throughput

0.489

High

469678

WFDC2
WAP four-disulfide core domain protein 2

1

0

Small-scale

0.479

High

217735

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

376463

LDLR
Low-density lipoprotein receptor

1

4

Small-scale

0.479

High

423997

ITB3
Integrin beta-3

1

14

Small-scale

0.479

High

431664

ITB1
Integrin beta-1

1

12

Small-scale

0.479

High

469671

NGAL
Neutrophil gelatinase-associated lipocalin

1

3

Small-scale

0.479

High

469675

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

469676

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

469683

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

469698

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

438023

CO5A2

1

20

High-throughput

0.445

High

456572

ANXA2
Annexin A2

1

2

Small-scale

0.445

High

469655

COBA1

1

20

High-throughput

0.445

High

469659

LEG3
Galectin-3

1

16

Small-scale

0.445

High

469663

CO8A1
Collagen alpha-1(VIII) chain

1

20

High-throughput

0.445

High

469674

COGA1

1

20

High-throughput

0.445

High

469679

PCOC1
Procollagen C-endopeptidase enhancer 1

1

4

Small-scale

0.445

High

469682

CODA1
Collagen alpha-1(XIII) chain

1

20

High-throughput

0.445

High

469685

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

20

High-throughput

0.445

High

469687

SCUB3
Signal peptide, CUB and EGF-like domain-containing protein 3

1

18

Small-scale

0.445

High

469690

COMA1

1

20

High-throughput

0.445

High

469697

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.445

High

469684

SCAR3
Scavenger receptor class A member 3

1

20

High-throughput

0.407

High


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Last updated: 11Aug2025