HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: AMHR2 (Q16671)
Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
Gene: AMHR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	22939624, 33961781, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0042803 - protein homodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 573
+	Hs
		438218 HS90B_HUMAN (19-732): 0: 1059: 86.13		AMHR2_HUMAN (1-573): 8.99e-140: 418: 100.00
+	Hs
		431603 HS90A_HUMAN (1-732): 0: 1087: 100.00		TGFR1_HUMAN (55-513): 7.01e-121: 367: 28.31
+	Hs
		431836 HS90A_HUMAN (1-732): 0: 1087: 100.00		AVR2B_HUMAN (8-544): 4.09e-120: 366: 26.29
+	Hs
		432072 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACV1C_HUMAN (49-513): 3.79e-116: 355: 27.55
+	Hs
		431601 HS90A_HUMAN (1-732): 0: 1087: 100.00		BMR1A_HUMAN (55-513): 4.37e-113: 348: 26.09
+	Hs
		431602 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACV1B_HUMAN (45-513): 1.36e-111: 343: 27.35
+	Hs
		438157 HS90B_HUMAN (19-732): 0: 1059: 86.13		AVR2B_HUMAN (8-544): 4.09e-120: 366: 26.29
+	Hs
		431607 HS90A_HUMAN (1-732): 0: 1087: 100.00		TGFR2_HUMAN (61-510): 6.44e-107: 333: 27.18
+	Hs
		438363 HS90B_HUMAN (19-732): 0: 1059: 86.13		ACV1C_HUMAN (49-513): 3.79e-116: 355: 27.55
+	Hs
		431606 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACVL1_HUMAN (57-513): 2.96e-103: 322: 26.03
+	Hs
		437951 HS90B_HUMAN (19-732): 0: 1059: 86.13		BMR1A_HUMAN (55-513): 4.37e-113: 348: 26.09
+	Hs
		437952 HS90B_HUMAN (19-732): 0: 1059: 86.13		ACV1B_HUMAN (45-513): 1.36e-111: 343: 27.35
+	Ce
		595733 HSP90_CAEEL (14-732): 0: 960: 74.83		DAF1_CAEEL (220-505): 2.2e-33: 137: 30.03
+	Ce
		839899 HSP90_CAEEL (14-732): 0: 960: 74.83		DAF4_CAEEL (67-505): 9.05e-26: 114: 26.13
+	Hs
		1086118 H90B4_HUMAN (30-604): 0: 571: 62.61		AMHR2_HUMAN (1-573): 8.99e-140: 418: 100.00