HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2
Common GO terms	GO:0001772 - immunological synapse GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0019901 - protein kinase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1655
+	Hs
		463515 LYN_HUMAN (1-509): 0: 581: 62.72		SCRIB_HUMAN (1-1655): 0: 940: 100.00
+	Hs
		440486 FYN_HUMAN (1-507): 0: 587: 54.19		DLG4_HUMAN (812-1187): 5.87e-49: 189: 22.42
+	Rn
		723904 SRC_RAT (27-507): 0: 582: 56.73		DLG4_RAT (812-1187): 5.61e-49: 189: 22.42
+	Mm
		431355 SRC_MOUSE (21-507): 0: 582: 56.24		DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42
+	Hs
		463738 LYN_HUMAN (1-509): 0: 581: 62.72		LRRC1_HUMAN (1-189): 8.84e-41: 161: 27.51
+	Hs
		440052 LCK_HUMAN (1-509): 0: 655: 100.00		DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68
+	Mm
		440284 LCK_MOUSE (1-509): 0: 652: 96.86		DLG1_MOUSE (688-910): 1.27e-14: 81.7: 23.91
+	Hs
		440180 LCK_HUMAN (1-509): 0: 655: 100.00		ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27
+	Hs
		463488 LYN_HUMAN (1-509): 0: 581: 62.72		DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68
+	Hs
		463716 LYN_HUMAN (1-509): 0: 581: 62.72		ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27