Protein: LCK
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)

Gene: LCK
Organism: Mus musculus
Interactions: 26
UniProt ID: P06240

Gene Ontology (top 5):
GO:0000242 - pericentriolar material
GO:0001772 - immunological synapse
GO:0001784 - phosphotyrosine residue binding
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440275

HCLS1
Hematopoietic lineage cell-specific protein

2

20

Small-scale

0.806

High

440274

ZAP70
Tyrosine-protein kinase ZAP-70

2

19

Small-scale

0.776

High

440286

SOCS6
Suppressor of cytokine signaling 6

1

19

Small-scale

0.740

High

440272

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.724

High

440267

PTPRC
Receptor-type tyrosine-protein phosphatase C

2

20

Small-scale

0.712

High

440266

CD4
T-cell surface glycoprotein CD4

4

1

Small-scale

0.670

High

440271

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.640

High

440287

STAP1
Signal-transducing adaptor protein 1

1

4

Small-scale

0.621

High

205165

FYB1
FYN-binding protein 1

1

16

Small-scale

0.618

High

440279

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

10

High-throughput

0.618

High

440280

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.618

High

440284

DLG1
Disks large homolog 1

1

15

Small-scale

0.618

High

440285

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

8

Small-scale

0.618

High

440289

STK11
Serine/threonine-protein kinase STK11

1

11

Small-scale

0.618

High

440288

SH22A
SH2 domain-containing protein 2A

1

19

Small-scale

0.584

High

440269

KPCE
Protein kinase C epsilon type

1

14

Small-scale

0.575

High

378888

CD8A
T-cell surface glycoprotein CD8 alpha chain

2

0

Small-scale

0.551

High

440282

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.515

High

440278

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.501

High

440276

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

1

Small-scale

0.479

High

440277

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.479

High

440283

FACD2
Fanconi anemia group D2 protein homolog

1

4

High-throughput

0.479

High

440268

CD44
CD44 antigen

1

6

Small-scale

0.445

High

440270

TNR9
Tumor necrosis factor receptor superfamily member 9

1

11

Small-scale

0.437

High

440273

CSF3R
Granulocyte colony-stimulating factor receptor

1

14

Small-scale

0.437

High

440281

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

1

1

Small-scale

0.407

High


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Last updated: 11Aug2025