HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: Q4LE69 (Q4LE69)
Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.80	0.687

Property	Details
Experiments	8246987, 34079125
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2, PI3Ka~SH2
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 2121
+	Hs
		463556 LYN_HUMAN (1-509): 0: 581: 62.72		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		439984 LCK_HUMAN (1-509): 0: 655: 100.00		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		439994 LCK_HUMAN (1-509): 0: 655: 100.00		PK3CG_HUMAN (1522-2119): 7.19e-133: 448: 19.56
+	Mm
		431353 SRC_MOUSE (21-507): 0: 582: 56.24		P3C2A_MOUSE (1411-2120): 1.79e-152: 519: 17.98
+	Mm
		440285 LCK_MOUSE (1-509): 0: 652: 96.86		PK3CG_MOUSE (1522-2119): 4.67e-131: 443: 19.87
+	Hs
		557155 SRC_HUMAN (20-507): 0: 585: 55.00		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		463401 LYN_HUMAN (1-509): 0: 581: 62.72		PK3CG_HUMAN (1522-2119): 7.19e-133: 448: 19.56