Protein: PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)

Gene: PK3CG, PIK3CG
Organism: Homo sapiens
Interactions: 40
UniProt ID: P48736

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001819 - positive regulation of cytokine production
GO:0002250 - adaptive immune response
GO:0002407 - dendritic cell chemotaxis
GO:0002675 - positive regulation of acute inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

463401

LYN
Tyrosine-protein kinase Lyn

2

11

Small-scale

0.819

High

877426

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

2

4

Small-scale

0.812

High

374461

RASH
GTPase HRas

2

20

Small-scale

0.767

High

132790

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

11

Small-scale

0.724

High

375287

RASK
GTPase KRas

1

20

Small-scale

0.724

High

877418

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

Small-scale

0.724

High

877422

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

4

Small-scale

0.724

High

877413

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

2

12

Small-scale

0.712

High

373831

RASN
GTPase NRas

1

20

Small-scale

0.647

High

439994

LCK
Tyrosine-protein kinase Lck

1

10

Small-scale

0.618

High

699647

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

849057

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.618

High

849124

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

877424

RASE
GTPase ERas

1

20

Small-scale

0.618

High

862613

UTRN
Utrophin

1

7

High-throughput

0.536

High

877414

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

877421

BECN1
Beclin-1

1

7

Small-scale

0.536

High

877423

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

4

High-throughput

0.536

High

877427

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

7

High-throughput

0.536

High

877429

ANM7
Protein arginine N-methyltransferase 7

1

3

High-throughput

0.536

High

421707

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

578421

BRAF
Serine/threonine-protein kinase B-raf

1

4

High-throughput

0.506

High

436630

KPCB
Protein kinase C beta type

1

8

Small-scale

0.501

High

877416

SET
Protein SET

1

0

Small-scale

0.480

High

877419

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

Small-scale

0.479

High

330758

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.479

High

520533

RARA
Retinoic acid receptor alpha

1

14

Small-scale

0.479

High

535913

CD37
Leukocyte antigen CD37

1

3

Small-scale

0.479

High

539975

BCR
Breakpoint cluster region protein

1

6

Small-scale

0.479

High

593735

PECA1
Platelet endothelial cell adhesion molecule

1

6

Small-scale

0.479

High

710682

EPHA8
Ephrin type-A receptor 8

1

17

Small-scale

0.479

High

715998

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

3

Small-scale

0.479

High

877415

CXCR4
C-X-C chemokine receptor type 4

1

15

Small-scale

0.479

High

877417

KPCZ
Protein kinase C zeta type

1

9

Small-scale

0.479

High

877428

IL1AP
Interleukin-1 receptor accessory protein

1

7

Small-scale

0.479

High

877430

ZN282
Zinc finger protein 282

1

1

High-throughput

0.464

High

220362

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

877425

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

877420

GAB1
GRB2-associated-binding protein 1

1

7

Small-scale

0.408

High


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Last updated: 11Aug2025