HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0035556 - intracellular signal transduction GO:0042169 - SH2 domain binding GO:0045121 - membrane raft
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Mm			1 429
+	Mm
		813516 FYN_MOUSE (1-507): 0: 589: 53.85		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		683095 LYN_MOUSE (1-509): 0: 564: 62.72		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		440227 LCK_HUMAN (1-509): 0: 633: 96.86		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		440751 FYN_HUMAN (1-507): 0: 589: 54.03		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		557496 SRC_HUMAN (2-507): 0: 576: 54.13		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		1043254 ITK_MOUSE (6-500): 3.38e-167: 488: 33.20		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		463801 LYN_HUMAN (1-509): 0: 564: 63.37		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		841030 FRK_HUMAN (33-503): 0: 520: 47.24		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		362387 ABL1_HUMAN (39-506): 1.31e-166: 502: 40.76		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		834233 CSK_HUMAN (59-500): 2.53e-174: 500: 37.80		PHAG1_HUMAN (1-429): 0: 705: 78.21