Protein: LYN
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)

Gene: LYN
Organism: Mus musculus
Interactions: 40
UniProt ID: P25911

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000902 - cell morphogenesis
GO:0001782 - B cell homeostasis
GO:0001817 - regulation of cytokine production
GO:0001933 - negative regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683090

HCLS1
Hematopoietic lineage cell-specific protein

2

20

Small-scale

0.793

High

683095

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

12

Small-scale

0.740

High

651476

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.676

High

683103

EFS
Embryonal Fyn-associated substrate

2

20

Small-scale

0.670

High

683108

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

17

Small-scale

0.665

High

683116

GAB2
GRB2-associated-binding protein 2

1

20

Small-scale

0.646

High

205166

FYB1
FYN-binding protein 1

1

16

Small-scale

0.618

High

683087

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

683088

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.618

High

683089

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

683093

DOK1
Docking protein 1

1

20

Small-scale

0.618

High

683096

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.618

High

683097

SH21C
SH2 domain-containing protein 1B2

1

19

Small-scale

0.618

High

683111

Q91YX7
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

683114

CLNK
Cytokine-dependent hematopoietic cell linker

1

20

Small-scale

0.618

High

683110

ANR54
Ankyrin repeat domain-containing protein 54

1

14

High-throughput

0.590

High

575627

EPOR
Erythropoietin receptor

1

19

Small-scale

0.575

High

683099

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.501

High

204643

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

11

Small-scale

0.500

High

107051

F8VPR5
histone acetyltransferase

1

15

Small-scale

0.479

High

108464

G3X9H5
Huntingtin

1

4

High-throughput

0.479

High

549724

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

2

Small-scale

0.479

High

633281

FCERB
High affinity immunoglobulin epsilon receptor subunit beta

1

3

Small-scale

0.479

High

683094

LIRB3
Paired immunoglobulin-like receptor B

1

20

Small-scale

0.479

High

683102

ITA2
Integrin alpha-2

1

6

Small-scale

0.479

High

683104

FCRL5
Fc receptor-like protein 5

1

18

Small-scale

0.479

High

683105

CLC7A
C-type lectin domain family 7 member A

1

3

Small-scale

0.479

High

683106

FACD2
Fanconi anemia group D2 protein homolog

1

4

High-throughput

0.479

High

683107

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.479

High

683112

Q9JM08
Histone deacetylase

1

1

Small-scale

0.479

High

86321

B9EKI5
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.457

High

683091

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

High-throughput

0.457

High

683109

RBM12
RNA-binding protein 12

1

7

High-throughput

0.457

High

683115

KLF5
Krueppel-like factor 5

1

5

High-throughput

0.457

High

683113

SRCN1
SRC kinase signaling inhibitor 1

1

8

High-throughput

0.445

High

267115

DOK2
Docking protein 2

1

20

Small-scale

0.436

High

683092

IRS2
Insulin receptor substrate 2

1

19

Small-scale

0.436

High

683098

SRC8
Src substrate cortactin

1

20

Small-scale

0.436

High

683100

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.436

High

683101

DBNL
Drebrin-like protein

1

20

Small-scale

0.436

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025