Interactor 1: ODPA (P08559)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene: PDHA1
Interactor 2: ODPB (P11177)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Gene: PDHB
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 7864652, 33961781, 29128334, 34079125, 19081061, 12651851 |
| Identification Methods | affinity chromatography technology, biochemical, proximity labelling technology, molecular sieving, x-ray crystallography, cross-linking study, isothermal titration calorimetry, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | E1_dh~Transket_pyr, E1_dh~Transketolase_C |
| Common GO terms | GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006006 - glucose metabolic process and 3 others more... |
| Homologous interactions | 15 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
