HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0010629 - negative regulation of gene expression
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 209
+	Hs
		481097 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		HMGB1_HUMAN (1-174): 1.65e-41: 141: 86.21
+	Hs
		667538 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		HMGB2_HUMAN (1-187): 6.47e-41: 139: 100.00
+	Hs
		443131 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		HMGB1_HUMAN (1-174): 1.65e-41: 141: 86.21
+	Hs
		687218 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		HMGB2_HUMAN (1-187): 6.47e-41: 139: 100.00
+	Hs
		443307 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		TFAM_HUMAN (9-190): 7.5e-31: 114: 21.68
+	Hs
		443259 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		SOX2_HUMAN (3-94): 1.21e-23: 97.5: 22.83
+	Hs
		604601 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		UBF1_HUMAN (10-158): 3.13e-09: 57.8: 24.72
+	Hs
		443483 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		CIC_HUMAN (3-91): 1.53e-11: 64.7: 22.47