HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: H11 (Q02539)
Histone H1.1 (Histone H1a)
Gene: H1-1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	0.60	0.767

Property	Details
Experiments	19107194, 22539978, 18695677, 16314512, 24571573, 21924351, 19223857, 20236090, 21871177, 15574121, 15554878, 17369848, 12734188, 10336450, 10362260, 9053846, 8397207, 8397206, 11836499, 7790358 and 4 others more... 9885575, 11687586, 23933584, 20974803
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030261 - chromosome condensation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 215
+	Rn
		441596 Q6P751_RAT (1-297): 5.58e-149: 421: 64.98		H1T_RAT (1-213): 4.77e-37: 130: 48.37
+	Hs
		595685 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		H13_HUMAN (1-169): 5.81e-27: 104: 55.03
+	Rn
		93227 Q6P751_RAT (1-297): 5.58e-149: 421: 64.98		H11_RAT (1-123): 9.45e-24: 95.9: 77.24
+	Hs
		595319 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		H15_HUMAN (1-118): 1.19e-22: 93.2: 72.88
+	Hs
		667793 CDK2_HUMAN (1-297): 4.63e-149: 421: 65.32		H11_HUMAN (1-199): 7.32e-21: 88.2: 100.00
+	Hs
		443158 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		H13_HUMAN (1-169): 5.81e-27: 104: 55.03
+	Rn
		93223 CDK1_RAT (1-297): 1.9e-142: 404: 97.64		H11_RAT (1-123): 9.45e-24: 95.9: 77.24
+	Hs
		443157 CDK1_HUMAN (1-297): 1.1e-142: 405: 100.00		H15_HUMAN (1-118): 1.19e-22: 93.2: 72.88
+	Mm
		847025 CDK2_MOUSE (1-297): 3.02e-140: 400: 55.94		H15_MOUSE (1-199): 6.2e-23: 94: 56.59
+	Mm
		543004 CDK1_MOUSE (1-297): 1.36e-141: 402: 96.97		H12_MOUSE (33-118): 1.43e-17: 79.4: 80.23
+	Mm
		543016 CDK1_MOUSE (1-297): 1.36e-141: 402: 96.97		H11_MOUSE (1-124): 1.62e-17: 79.4: 79.84
+	Mm
		586400 CDK2_MOUSE (1-297): 3.02e-140: 400: 55.94		H12_MOUSE (33-118): 1.43e-17: 79.4: 80.23
+	Mm
		847012 CDK2_MOUSE (1-297): 3.02e-140: 400: 55.94		H11_MOUSE (1-124): 1.62e-17: 79.4: 79.84
+	Hs
		596045 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		H12_HUMAN (32-175): 4.85e-23: 94: 54.86
+	Hs
		595396 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		H15_HUMAN (1-118): 1.19e-22: 93.2: 72.88
+	Hs
		521646 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		H14_HUMAN (1-149): 9.64e-22: 90.5: 63.76
+	Hs
		1025447 CDK5_HUMAN (1-293): 8.35e-134: 382: 56.12		H11_HUMAN (1-199): 7.32e-21: 88.2: 100.00
+	Mm
		847008 CDK5_MOUSE (1-293): 1.24e-133: 381: 56.12		H11_MOUSE (1-124): 1.62e-17: 79.4: 79.84