HitPredict

Interactor 1: EVE (P06602)
Segmentation protein even-skipped
Gene: EVE

Interactor 2: UBX (P83949)
Homeotic protein ultrabithorax
Gene: UBX

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25869471, 30247122
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Dm			1 389
+	Dm
		1014427 Q9XZU0_DROME (62-368): 1.62e-38: 142: 19.20		UBX_DROME (1-389): 1.59e-123: 363: 100.00
+	Dm
		1014305 AL_DROME (30-315): 4.09e-37: 140: 24.84		UBX_DROME (1-389): 1.59e-123: 363: 100.00
+	Dm
		444061 EVE_DROME (1-376): 2.64e-42: 153: 100.00		ABDA_DROME (260-376): 6.82e-42: 156: 59.32
+	Dm
		444043 PRD_DROME (16-347): 1.71e-39: 150: 19.52		ABDA_DROME (260-376): 6.82e-42: 156: 59.32
+	Dm
		713743 Q9XZU0_DROME (62-368): 1.62e-38: 142: 19.20		ABDA_DROME (260-376): 6.82e-42: 156: 59.32
+	Dm
		713666 AL_DROME (30-315): 4.09e-37: 140: 24.84		ABDA_DROME (260-376): 6.82e-42: 156: 59.32
+	Hs
		574012 HXB2_HUMAN (25-271): 7.01e-36: 135: 24.50		HXB2_HUMAN (240-385): 2.16e-41: 151: 38.10
+	Hs
		214512 HXA3_HUMAN (14-260): 5.33e-40: 148: 23.19		ALX4_HUMAN (94-388): 2.05e-34: 133: 16.27
+	Hs
		724919 HXD3_HUMAN (14-269): 4.71e-40: 148: 22.96		ALX4_HUMAN (94-388): 2.05e-34: 133: 16.27
+	Dm
		393612 EVE_DROME (1-376): 2.64e-42: 153: 100.00		ANTP_DROME (161-375): 3.4e-31: 123: 32.56
+	Mm
		478355 HXD3_MOUSE (33-269): 8.45e-42: 153: 25.50		MEOX2_MOUSE (114-366): 1.28e-30: 120: 19.76
+	Mm
		204328 PAX3_MOUSE (44-319): 7.05e-33: 130: 19.57		ALX4_MOUSE (94-388): 2.24e-36: 138: 17.57
+	Hs
		724911 HXD3_HUMAN (14-269): 4.71e-40: 148: 22.96		HXC8_HUMAN (146-363): 1.05e-30: 119: 29.86
+	Mm
		204351 Q8VD35_MOUSE (35-260): 1.16e-33: 128: 20.88		ALX4_MOUSE (94-388): 2.24e-36: 138: 17.57
+	Dm
		444055 EVE_DROME (1-376): 2.64e-42: 153: 100.00		SCR_DROME (289-353): 5.68e-24: 104: 80.00
+	Hs
		484819 HXA7_HUMAN (44-145): 1.22e-34: 129: 32.11		HXB7_HUMAN (162-364): 3.83e-33: 124: 32.02
+	Mm
		666045 PAX3_MOUSE (44-319): 7.05e-33: 130: 19.57		MEOX1_MOUSE (149-378): 1.21e-31: 122: 18.93
+	Mm
		666046 PAX3_MOUSE (44-319): 7.05e-33: 130: 19.57		MEOX2_MOUSE (114-366): 1.28e-30: 120: 19.76
+	Dm
		393654 PRD_DROME (16-347): 1.71e-39: 150: 19.52		FTZ_DROME (296-353): 9.82e-22: 97.8: 79.31
+	Dm
		478761 HMPB_DROME (25-134): 7.35e-33: 131: 40.00		SCR_DROME (289-353): 5.68e-24: 104: 80.00