HitPredict

Interactor 1: ALX4 (O35137)
Homeobox protein aristaless-like 4 (ALX-4)
Gene: ALX4

Interactor 2: Q8VD35 (Q8VD35)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 399 Mm			1 289
+	Mm
		204350 ALX4_MOUSE (1-399): 2.46e-84: 264: 100.00		Q8R0B5_MOUSE (1-289): 1.48e-69: 218: 96.63
+	Mm
		204322 ALX4_MOUSE (1-399): 2.46e-84: 264: 100.00		ALX4_MOUSE (3-237): 2.7e-35: 132: 24.37
+	Mm
		204328 ALX4_MOUSE (1-399): 2.46e-84: 264: 100.00		PAX3_MOUSE (12-256): 1.57e-34: 131: 27.76
+	Hs
		1152409 ALX4_HUMAN (1-399): 5.76e-79: 251: 89.78		ALX1_HUMAN (2-237): 1.01e-38: 140: 25.11
+	Mm
		204324 ALX4_MOUSE (1-399): 2.46e-84: 264: 100.00		LMX1B_MOUSE (1-229): 1.89e-32: 124: 17.92
+	Hs
		1430818 ALX4_HUMAN (1-399): 5.76e-79: 251: 89.78		ALX4_HUMAN (14-237): 1.98e-34: 130: 23.45
+	Hs
		733239 LHX1_HUMAN (150-382): 2.91e-38: 144: 27.66		OTX2_HUMAN (1-289): 5.1e-74: 230: 99.31
+	Bt
		1275062 RAX2_BOVIN (199-328): 8.68e-42: 147: 41.22		CRX_BOVIN (1-289): 4.86e-38: 137: 46.58
+	Hs
		210085 RAX2_HUMAN (197-327): 7.38e-39: 139: 42.42		CRX_HUMAN (1-289): 5.22e-40: 143: 46.91
+	Hs
		877572 LHX1_HUMAN (150-382): 2.91e-38: 144: 27.66		LHX3_HUMAN (39-264): 3.8e-36: 134: 21.46
+	Hs
		724919 HXD3_HUMAN (8-376): 8.45e-39: 145: 17.29		ALX4_HUMAN (14-237): 1.98e-34: 130: 23.45
+	Hs
		700820 PIT1_HUMAN (2-267): 1.82e-38: 141: 13.03		PITX1_HUMAN (16-259): 1.13e-33: 126: 26.61
+	Hs
		1005635 PITX1_HUMAN (138-393): 8.86e-34: 129: 28.04		PITX2_HUMAN (4-259): 2.71e-37: 136: 23.76
+	Hs
		1406443 PITX2_HUMAN (175-393): 6.11e-33: 127: 28.39		PITX2_HUMAN (4-259): 2.71e-37: 136: 23.76
+	Mm
		204323 RX_MOUSE (122-395): 4.42e-34: 131: 29.08		ALX4_MOUSE (3-237): 2.7e-35: 132: 24.37
+	Hs
		184760 SHOX_HUMAN (190-395): 1.06e-36: 137: 29.13		SHOX_HUMAN (22-103): 3.86e-32: 121: 51.22
+	Mm
		1000075 PITX1_MOUSE (138-393): 3.23e-33: 128: 27.57		PITX1_MOUSE (14-259): 5.11e-34: 127: 27.20