HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: MYO19 (Q96H55)
Unconventional myosin-XIX (Myosin head domain-containing protein 1)
Gene: MYO19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Myosin_head~Tropomyosin
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0007015 - actin filament organization GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 970
+	Hs
		482951 TPM1_HUMAN (2-285): 1.36e-44: 154: 91.20		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		464198 TPM2_HUMAN (2-285): 1.41e-40: 143: 86.27		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		116469 H7BYY1_HUMAN (41-285): 5.71e-36: 130: 64.90		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		995462 TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96		MYO19_HUMAN (1-970): 0: 1069: 100.00
+	Hs
		447692 TPM3_HUMAN (1-285): 1.29e-44: 154: 100.00		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		482842 TPM1_HUMAN (2-285): 1.36e-44: 154: 91.20		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		464124 TPM2_HUMAN (2-285): 1.41e-40: 143: 86.27		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		116462 H7BYY1_HUMAN (41-285): 5.71e-36: 130: 64.90		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Hs
		772732 TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96		MYH9_HUMAN (9-907): 0: 997: 28.63
+	Dm
		447919 TPM1_DROME (44-282): 3.15e-32: 123: 55.23		Q59E59_DROME (9-898): 0: 986: 28.21
+	Hs
		1458286 EP15R_HUMAN (155-285): 8.49e-10: 61.1: 20.61		MYO6_HUMAN (50-677): 1.7e-119: 397: 36.01