Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 25495026, 19727205, 24474694
Identification Methods affinity chromatography technology, solid phase assay, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005576 - extracellular region
GO:0006954 - inflammatory response
GO:0009986 - cell surface
GO:0031175 - neuron projection development
GO:0032735 - positive regulation of interleukin-12 production
and 6 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 215
Hs

1 404
+ Mm
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024