HitPredict

Interactor 1: CRUM1 (P82279)
Protein crumbs homolog 1
Gene: CRB1

Interactor 2: E41L5 (Q9HCM4)
Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)
Gene: EPB41L5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.605

Property	Details
Experiments	31462741, 17920587
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001917 - photoreceptor inner segment GO:0005886 - plasma membrane GO:0005912 - adherens junction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1406 Hs			1 733
+	Hs
		1126606 CRUM2_HUMAN (34-184): 1.36e-09: 65.1: 26.62		E41L5_HUMAN (1-733): 0: 689: 100.00
+	Hs
		547016 NOTC2_HUMAN (486-1399): 1.15e-72: 271: 17.03		EZRI_HUMAN (40-638): 3.48e-138: 420: 21.27
+	Hs
		980545 NOTC2_HUMAN (486-1399): 1.15e-72: 271: 17.03		E41LA_HUMAN (40-687): 2.13e-119: 375: 27.04
+	Dm
		49536 CRB_DROME (824-1119): 3.94e-11: 70.5: 14.52		A0T1Z5_DROME (6-733): 4.26e-167: 502: 37.61
+	Dm
		706641 FAT_DROME (1045-1213): 8.47e-27: 121: 22.78		EPB41_DROME (17-721): 1.51e-134: 437: 22.40
+	Hs
		946792 CRUM1_HUMAN (2-148): 2.39e-13: 77.4: 21.05		E41LB_HUMAN (1-722): 9e-157: 479: 42.79
+	Mm
		1321810 NRX1A_MOUSE (952-1177): 2.65e-13: 77.4: 19.22		E41L3_MOUSE (35-727): 2.99e-153: 470: 27.12
+	Dm
		422941 NOTCH_DROME (5-315): 3.12e-22: 107: 21.37		Q9W0R3_DROME (1-637): 1.4e-126: 402: 26.03
+	Dm
		706599 FAT_DROME (1045-1213): 8.47e-27: 121: 22.78		MOEH_DROME (38-638): 1.49e-125: 387: 17.83
+	Hs
		640088 CRUM1_HUMAN (2-148): 2.39e-13: 77.4: 21.05		MOES_HUMAN (40-638): 9.72e-127: 390: 20.46
+	Mm
		640200 NRX1A_MOUSE (952-1177): 2.65e-13: 77.4: 19.22		MOES_MOUSE (40-638): 7.49e-125: 386: 20.29
+	Dm
		484984 CRB_DROME (824-1119): 3.94e-11: 70.5: 14.52		MOEH_DROME (38-638): 1.49e-125: 387: 17.83