Protein: PDCD4
Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)

Gene: PDCD4
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q53EL6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953906

IF4A1
Eukaryotic initiation factor 4A-I

10

15

Small-scale

0.977

High

1124261

IF4A2
Eukaryotic initiation factor 4A-II

5

15

High-throughput

0.930

High

807451

IF4A3
Eukaryotic initiation factor 4A-III

5

17

High-throughput

0.925

High

1047022

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

3

Small-scale

0.776

High

1198227

FBW1A
F-box/WD repeat-containing protein 1A

9

5

Small-scale

0.754

High

1198222

FBW1B
F-box/WD repeat-containing protein 11

7

5

Small-scale

0.743

High

1198187

DDX60
Probable ATP-dependent RNA helicase DDX60

1

2

High-throughput

0.691

High

859312

RL5
Large ribosomal subunit protein uL18

2

1

Small-scale

0.636

High

1198210

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

5

High-throughput

0.618

High

1198184

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

1

High-throughput

0.609

High

1182833

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

4

High-throughput

0.602

High

1198186

TF2LY
Homeobox protein TGIF2LY

2

0

High-throughput

0.602

High

1198193

H2B1H
Histone H2B type 1-H

2

8

High-throughput

0.601

High

1045358

TF65
Transcription factor p65

2

0

Small-scale

0.585

High

132085

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

2

Small-scale

0.584

High

588845

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

980814

H2B1C
Histone H2B type 1-C/E/F/G/I

2

8

High-throughput

0.584

High

1067418

EP300
Histone acetyltransferase p300

2

2

High-throughput

0.584

High

1198182

SLN11
Schlafen family member 11

2

1

Small-scale

0.584

High

1198195

H2B1A
Histone H2B type 1-A

2

8

High-throughput

0.584

High

426511

HMGN2
Non-histone chromosomal protein HMG-17

2

0

High-throughput

0.576

High

858671

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

1

High-throughput

0.571

High

387426

APOE
Apolipoprotein E

1

0

High-throughput

0.565

High

1101830

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.561

High

1198204

MEP50
Methylosome protein WDR77

1

3

Small-scale

0.561

High

1198215

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

Small-scale

0.561

High

1198198

EP400
E1A-binding protein p400

1

3

High-throughput

0.553

High

973199

RS13
Small ribosomal subunit protein uS15

1

1

Small-scale

0.552

High

997760

CSK21
Casein kinase II subunit alpha

1

6

High-throughput

0.550

High

1198188

ABI1
Abl interactor 1

2

0

High-throughput

0.547

High

890745

PSN2
Presenilin-2

1

2

High-throughput

0.539

High

288664

NPM3
Nucleoplasmin-3

1

3

High-throughput

0.536

High

295185

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

6

High-throughput

0.536

High

303568

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

407097

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.536

High

431152

LA
Lupus La protein

1

4

High-throughput

0.536

High

447085

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

479426

SRP19
Signal recognition particle 19 kDa protein

1

1

High-throughput

0.536

High

884108

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

969897

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

973463

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

985694

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

992783

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1136018

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1198191

PSPC1
Paraspeckle component 1

1

7

High-throughput

0.536

High

1198205

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1198216

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

2

High-throughput

0.536

High

1198221

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

1198224

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

1198226

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1198228

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.536

High

658605

KS6B1
Ribosomal protein S6 kinase beta-1

1

3

Small-scale

0.515

High

943363

H2BFS
Histone H2B type F-S

1

8

High-throughput

0.515

High

946793

H2B1D
Histone H2B type 1-D

1

8

High-throughput

0.515

High

1162952

H2B2E
Histone H2B type 2-E

1

8

High-throughput

0.515

High

1198203

H2B1M
Histone H2B type 1-M

1

8

High-throughput

0.515

High

162591

ANM5
Protein arginine N-methyltransferase 5

1

3

Small-scale

0.501

High

185752

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

964313

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

1148341

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

Small-scale

0.501

High

1198177

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.501

High

385807

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.493

High

1198223

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.489

High

889997

PSN1
Presenilin-1

1

2

High-throughput

0.481

High

130488

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

172887

XPO1
Exportin-1

1

7

High-throughput

0.479

High

241874

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

245113

AQR
RNA helicase aquarius

1

1

High-throughput

0.479

High

256881

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.479

High

449727

H2B1J
Histone H2B type 1-J

1

8

High-throughput

0.479

High

485183

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

695622

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

830851

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

862862

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.479

High

867180

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

934702

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

979767

H4
Histone H4

1

1

High-throughput

0.479

High

987056

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.479

High

987375

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.479

High

988133

TRA2B
Transformer-2 protein homolog beta

1

5

High-throughput

0.479

High

998387

H31
Histone H3.1

1

1

High-throughput

0.479

High

1039513

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.479

High

1107788

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1114865

CUL4A
Cullin-4A

1

2

Small-scale

0.479

High

1137745

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1138282

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1198180

ATAD2
ATPase family AAA domain-containing protein 2

1

4

High-throughput

0.479

High

1198181

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1198183

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1198201

RSF1
Remodeling and spacing factor 1

1

5

High-throughput

0.479

High

1198202

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1198208

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

Small-scale

0.479

High

1198211

ANLN
Anillin

1

1

High-throughput

0.479

High

1198214

DTL
Denticleless protein homolog

1

2

Small-scale

0.479

High

1198217

KS6B2
Ribosomal protein S6 kinase beta-2

1

3

High-throughput

0.479

High

1198219

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1198220

TCF20
Transcription factor 20

1

1

High-throughput

0.479

High

1198229

RBM8A
RNA-binding protein 8A

1

5

High-throughput

0.479

High

894789

EMD
Emerin

1

0

Small-scale

0.458

High

948850

CD81
CD81 antigen

1

0

High-throughput

0.458

High

1089306

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

0

High-throughput

0.458

High

1135697

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1198179

ARID2
AT-rich interactive domain-containing protein 2

1

0

High-throughput

0.458

High

1198192

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1198197

INT12
Integrator complex subunit 12

1

0

High-throughput

0.458

High

1198199

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1198209

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

1198213

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1198218

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

1198225

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.458

High

142347

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

728276

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.445

High

1056766

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.445

High

1198178

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

428157

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.438

High

412039

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

768348

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

879161

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1198189

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1198194

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.437

High

516524

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

911263

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.426

High

1198196

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

1198206

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

62537

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

1198185

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.407

High

1198200

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.407

High

1198207

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

2

High-throughput

0.407

High

1198212

TMM51
Transmembrane protein 51

3

0

High-throughput

0.347

High

65765

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

330183

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1198190

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025