Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: PDIA2 (Q13087)
Protein disulfide-isomerase A2 (EC 5.3.4.1) (Pancreas-specific protein disulfide isomerase) (PDIp)
Gene: PDIA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 35575683, 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6, Thioredoxin_6~Thioredoxin_6
Common GO terms GO:0003756 - protein disulfide isomerase activity
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006457 - protein folding
GO:0015035 - protein-disulfide reductase activity
and 2 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 508
Hs

1 525
+ Hs
+ Mm
+ Hs
+ Sc
+ Sc
+ Hs
+ Hs
+ Mm
+ Ce
+ Dm
+ Dm
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Nc
+ Rn

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Last updated: 11Aug2025