HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	17620338
Identification Methods	coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 906
+	Mm
		404008 PGFRB_MOUSE (1-1106): 0: 801: 85.44		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		557035 PGFRA_HUMAN (3-1106): 0: 716: 42.48		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		452407 PGFRB_HUMAN (1-1106): 0: 795: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		499234 KIT_HUMAN (3-1003): 0: 601: 29.99		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		403532 KIT_MOUSE (24-1004): 0: 603: 31.01		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		610268 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		499262 KIT_HUMAN (3-1003): 0: 601: 29.99		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		601457 FGFR2_HUMAN (9-326): 2.34e-58: 218: 11.51		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		572586 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		CBL_HUMAN (1-906): 0: 917: 100.00
+	Rn
		88773 VGFR1_RAT (3-613): 1.51e-58: 222: 20.86		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Mm
		610553 VGFR1_MOUSE (64-792): 2.64e-38: 158: 9.98		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		607879 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBL_HUMAN (1-906): 0: 917: 100.00
+	Dm
		112207 M9MRE1_DROME (32-503): 7e-43: 173: 16.67		O46034_DROME (47-460): 0: 746: 70.84
+	Hs
		607956 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		608187 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		203204 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		508077 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67
+	Hs
		508152 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Rn
		94375 FGFR1_RAT (16-326): 1.82e-20: 99.6: 13.43		F1M9G7_RAT (544-894): 3.04e-09: 63.4: 11.58
+	Hs
		608028 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		PHLB1_HUMAN (503-868): 1.01e-10: 68: 9.74