Protein: PTPRO
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)

Gene: PTPRO
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q16827

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0002548 - monocyte chemotaxis
GO:0003093 - regulation of glomerular filtration
GO:0003105 - negative regulation of glomerular filtration
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1163773

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

16

Small-scale

0.793

High

431824

ITB1
Integrin beta-1

2

6

High-throughput

0.789

High

1101730

PTK7
Inactive tyrosine-protein kinase 7

2

20

High-throughput

0.789

High

472072

MET
Hepatocyte growth factor receptor

2

20

High-throughput

0.776

High

1131273

GANAB
Neutral alpha-glucosidase AB

2

4

High-throughput

0.754

High

1163826

COR1C
Coronin-1C

1

4

High-throughput

0.691

High

1163815

SDF2L
Stromal cell-derived factor 2-like protein 1

3

2

High-throughput

0.656

High

1163821

DJB11
DnaJ homolog subfamily B member 11

3

3

High-throughput

0.656

High

1163829

HYOU1
Hypoxia up-regulated protein 1

3

5

High-throughput

0.656

High

422202

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.647

High

170506

RAB7L
Ras-related protein Rab-7L1

1

7

High-throughput

0.618

High

171709

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.618

High

320873

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

7

High-throughput

0.618

High

409402

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.618

High

462881

LAMB1
Laminin subunit beta-1

1

7

High-throughput

0.618

High

520863

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.618

High

522670

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

16

High-throughput

0.618

High

532084

KIT
Mast/stem cell growth factor receptor Kit

1

17

Small-scale

0.618

High

535846

LAMC1
Laminin subunit gamma-1

1

7

High-throughput

0.618

High

572690

NID1
Nidogen-1

1

3

High-throughput

0.618

High

607375

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

4

High-throughput

0.618

High

710272

EPHA2
Ephrin type-A receptor 2

1

12

High-throughput

0.618

High

849181

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

937401

LAMB2
Laminin subunit beta-2

1

6

High-throughput

0.618

High

1163784

AN13A
Ankyrin repeat domain-containing protein 13A

1

2

High-throughput

0.618

High

1163808

RAB34
Ras-related protein Rab-34

1

5

High-throughput

0.618

High

1098405

DNJC3
DnaJ homolog subfamily C member 3

2

9

High-throughput

0.611

High

566690

PDIA4
Protein disulfide-isomerase A4

3

13

High-throughput

0.599

High

1163776

CNNM4
Metal transporter CNNM4

1

0

High-throughput

0.586

High

390592

TFR1
Transferrin receptor protein 1

2

0

High-throughput

0.585

High

452273

PDIA1
Protein disulfide-isomerase

2

13

High-throughput

0.584

High

697898

CALR
Calreticulin

2

9

High-throughput

0.584

High

698700

CALX
Calnexin

2

9

High-throughput

0.584

High

717488

PDIA3
Protein disulfide-isomerase A3

2

14

High-throughput

0.584

High

880564

LMAN1
Protein ERGIC-53

2

2

High-throughput

0.584

High

934685

TERA
Transitional endoplasmic reticulum ATPase

2

3

Small-scale

0.584

High

1142282

PDIA6
Protein disulfide-isomerase A6

2

14

High-throughput

0.584

High

1143614

NOMO1
BOS complex subunit NOMO1

2

2

High-throughput

0.584

High

1163795

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

2

1

High-throughput

0.584

High

1163807

ERP44
Endoplasmic reticulum resident protein 44

2

14

High-throughput

0.584

High

1163818

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

4

High-throughput

0.584

High

1163825

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

2

1

High-throughput

0.584

High

193584

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

6

High-throughput

0.575

High

410876

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

412010

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

439748

INSR
Insulin receptor

1

20

High-throughput

0.575

High

440094

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

484152

PGFRB
Platelet-derived growth factor receptor beta

1

19

High-throughput

0.575

High

619224

EPOR
Erythropoietin receptor

1

20

High-throughput

0.575

High

651350

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.575

High

691760

MK03
Mitogen-activated protein kinase 3

1

14

High-throughput

0.575

High

834193

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

840885

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

1038441

TIE2
Angiopoietin-1 receptor

1

18

High-throughput

0.575

High

1163787

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.559

High

1163831

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

0

High-throughput

0.559

High

175373

PLXB2
Plexin-B2

1

17

High-throughput

0.536

High

571445

GLU2B
Glucosidase 2 subunit beta

2

3

High-throughput

0.533

High

1105464

OS9
Protein OS-9

2

1

High-throughput

0.533

High

1163797

ERLEC
Endoplasmic reticulum lectin 1

2

1

High-throughput

0.533

High

1163802

SDF2
Stromal cell-derived factor 2

2

2

High-throughput

0.533

High

1163811

TMX1
Thioredoxin-related transmembrane protein 1

2

17

High-throughput

0.533

High

1163822

SE1L1
Protein sel-1 homolog 1

2

2

High-throughput

0.533

High

1163828

DJC16
DnaJ homolog subfamily C member 16

2

19

High-throughput

0.533

High

990277

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.508

High

1163803

SH3G1
Endophilin-A2

1

10

High-throughput

0.508

High

1163804

SH3G3
Endophilin-A3

1

8

High-throughput

0.508

High

127977

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

5

High-throughput

0.479

High

128245

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

6

High-throughput

0.479

High

130117

PGRC1
Membrane-associated progesterone receptor component 1

1

3

High-throughput

0.479

High

136501

GOLI4
Golgi integral membrane protein 4

1

3

High-throughput

0.479

High

249246

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

1

High-throughput

0.479

High

251901

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

3

High-throughput

0.479

High

386470

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

480473

VILI
Villin-1

1

1

Small-scale

0.479

High

535119

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

609691

LEG3
Galectin-3

1

20

High-throughput

0.479

High

610347

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

613063

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

656139

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.479

High

813104

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

888882

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

894420

MMP14
Matrix metalloproteinase-14

1

2

High-throughput

0.479

High

1038872

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

3

High-throughput

0.479

High

1098001

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.479

High

1120733

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

1146550

TMED2
Transmembrane emp24 domain-containing protein 2

1

1

High-throughput

0.479

High

1163775

P210L
Nuclear pore membrane glycoprotein 210-like

1

2

High-throughput

0.479

High

1163777

CD109
CD109 antigen

1

1

High-throughput

0.479

High

1163778

QSOX2
Sulfhydryl oxidase 2

1

14

High-throughput

0.479

High

1163779

TMTC3
Protein O-mannosyl-transferase TMTC3

1

3

High-throughput

0.479

High

1163783

DJC10
DnaJ homolog subfamily C member 10

1

19

High-throughput

0.479

High

1163788

PO210
Nuclear pore membrane glycoprotein 210

1

2

High-throughput

0.479

High

1163790

NICA
Nicastrin

1

1

High-throughput

0.479

High

1163796

ASTRA
Protein Aster-A

1

1

High-throughput

0.479

High

1163798

ERO1A
ERO1-like protein alpha

1

1

High-throughput

0.479

High

1163801

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.479

High

1163805

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.479

High

1163813

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1163817

DJB12
DnaJ homolog subfamily B member 12

1

5

High-throughput

0.479

High

1163824

LCAP
Leucyl-cystinyl aminopeptidase

1

1

High-throughput

0.479

High

1163827

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.479

High

1163830

SRPRB
Signal recognition particle receptor subunit beta

1

4

High-throughput

0.479

High

319803

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

61110

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.458

High

292644

RENR
Renin receptor

1

0

High-throughput

0.458

High

299988

CBPD
Carboxypeptidase D

1

0

High-throughput

0.458

High

316503

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.458

High

338625

AGRL2
Adhesion G protein-coupled receptor L2

1

0

High-throughput

0.458

High

418162

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

467505

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

1085998

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.458

High

1122609

MLEC
Malectin

1

0

High-throughput

0.458

High

1155219

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

1163774

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.458

High

1163782

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.458

High

1163785

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1163791

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1163792

EXT2
Exostosin-2

1

0

High-throughput

0.458

High

1163793

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.458

High

1163794

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.458

High

1163816

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.458

High

1163820

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.458

High

993197

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.457

High

618257

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

764796

CTNB1
Catenin beta-1

1

19

High-throughput

0.445

High

842655

WASP
Actin nucleation-promoting factor WAS

1

6

High-throughput

0.445

High

857117

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.445

High

878472

PAXI
Paxillin

1

10

High-throughput

0.445

High

170779

CLGN
Calmegin

1

9

High-throughput

0.437

High

220916

XPOT
Exportin-T

1

13

High-throughput

0.437

High

827194

ARL1
ADP-ribosylation factor-like protein 1

1

4

High-throughput

0.437

High

1147522

UBE3C
Ubiquitin-protein ligase E3C

1

3

High-throughput

0.437

High

1163786

TTC13
Tetratricopeptide repeat protein 13

1

4

High-throughput

0.437

High

1163789

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.437

High

1163800

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

8

High-throughput

0.437

High

1163810

TMX4
Thioredoxin-related transmembrane protein 4

1

16

High-throughput

0.437

High

1163814

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

1

High-throughput

0.437

High

1106479

GAB1
GRB2-associated-binding protein 1

1

5

High-throughput

0.407

High

1163799

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

2

0

High-throughput

0.305

High

1163809

SIL1
Nucleotide exchange factor SIL1

2

0

High-throughput

0.305

High

1163781

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.279

Low

1163823

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.269

Low

155855

DPYL4
Dihydropyrimidinase-related protein 4

1

0

High-throughput

0.265

Low

1163780

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.265

Low

252526

SEP15
Selenoprotein F

1

0

High-throughput

0.249

Low

350598

TXD12
Thioredoxin domain-containing protein 12

1

0

High-throughput

0.249

Low

904781

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

952433

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.249

Low

956060

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.249

Low

1136734

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.249

Low

1163806

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.249

Low

1163812

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1163819

CNIH4
Protein cornichon homolog 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025