HitPredict

Interactor 1: SEC4 (P07560)
Ras-related protein SEC4 (Suppressor of RHO3 protein 6)
Gene: SEC4

Interactor 2: RAEP (P32864)
Rab proteins geranylgeranyltransferase component A (Rab escort protein) (REP)
Gene: MRS6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.80	0.794

Property	Details
Experiments	10893259, 26918858, 18467557, 22615397
Identification Methods	affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Sc			1 603
+	Sc
		376282 YPT1_YEAST (13-215): 1.77e-84: 250: 47.09		RAEP_YEAST (1-603): 0: 843: 100.00
+	Hs
		724464 RAB1A_HUMAN (10-215): 7.21e-85: 251: 49.28		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		724502 RAB8B_HUMAN (13-211): 1.48e-84: 250: 54.00		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Mm
		894618 RAB1A_MOUSE (10-215): 7.21e-85: 251: 49.28		GDIA_MOUSE (45-434): 2.78e-176: 508: 25.76
+	Hs
		724515 RAB1B_HUMAN (13-215): 2.51e-83: 247: 49.02		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		724463 RB11A_HUMAN (10-215): 1.17e-82: 246: 39.44		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		894530 RAB1A_HUMAN (10-215): 7.21e-85: 251: 49.28		GDIB_HUMAN (45-434): 6.82e-174: 502: 26.26
+	Hs
		894580 RAB8B_HUMAN (13-211): 1.48e-84: 250: 54.00		GDIB_HUMAN (45-434): 6.82e-174: 502: 26.26
+	Hs
		894591 RAB1B_HUMAN (13-215): 2.51e-83: 247: 49.02		GDIB_HUMAN (45-434): 6.82e-174: 502: 26.26
+	Hs
		894529 RB11A_HUMAN (10-215): 1.17e-82: 246: 39.44		GDIB_HUMAN (45-434): 6.82e-174: 502: 26.26
+	Sc
		376305 YPT1_YEAST (13-215): 1.77e-84: 250: 47.09		GDI1_YEAST (45-433): 5.52e-154: 451: 24.18
+	Sc
		458569 SEC4_YEAST (1-215): 2.16e-82: 245: 100.00		GDI1_YEAST (45-433): 5.52e-154: 451: 24.18
+	Hs
		664861 RAB1A_HUMAN (10-215): 7.21e-85: 251: 49.28		RAE1_HUMAN (44-104): 3.14e-17: 87.5: 39.34
+	Hs
		664892 RAB8B_HUMAN (13-211): 1.48e-84: 250: 54.00		RAE1_HUMAN (44-104): 3.14e-17: 87.5: 39.34
+	Hs
		686572 RAB1A_HUMAN (10-215): 7.21e-85: 251: 49.28		RAE2_HUMAN (44-103): 9.76e-17: 85.9: 41.67
+	Hs
		686587 RAB8B_HUMAN (13-211): 1.48e-84: 250: 54.00		RAE2_HUMAN (44-103): 9.76e-17: 85.9: 41.67
+	Hs
		664903 RAB1B_HUMAN (13-215): 2.51e-83: 247: 49.02		RAE1_HUMAN (44-104): 3.14e-17: 87.5: 39.34
+	Hs
		664860 RB11A_HUMAN (10-215): 1.17e-82: 246: 39.44		RAE1_HUMAN (44-104): 3.14e-17: 87.5: 39.34
+	Hs
		686592 RAB1B_HUMAN (13-215): 2.51e-83: 247: 49.02		RAE2_HUMAN (44-103): 9.76e-17: 85.9: 41.67
+	Hs
		686571 RB11A_HUMAN (10-215): 1.17e-82: 246: 39.44		RAE2_HUMAN (44-103): 9.76e-17: 85.9: 41.67