HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 583
+	Hs
		468101 HS90B_HUMAN (19-732): 0: 1057: 86.13		SHC1_HUMAN (1-583): 0: 529: 100.00
+	Hs
		461117 HS90A_HUMAN (1-732): 0: 1085: 100.00		FER_HUMAN (345-581): 4.36e-41: 161: 18.75
+	Hs
		461050 HS90A_HUMAN (1-732): 0: 1085: 100.00		HCK_HUMAN (348-575): 6.63e-42: 160: 17.16
+	Hs
		461292 HS90A_HUMAN (1-732): 0: 1085: 100.00		BMX_HUMAN (341-582): 1.13e-38: 153: 19.69
+	Hs
		456083 HS90A_HUMAN (1-732): 0: 1085: 100.00		FES_HUMAN (326-581): 1.81e-37: 150: 21.79
+	Rn
		1013219 HS90A_RAT (1-732): 0: 1083: 97.95		GRB7_RAT (371-563): 2.32e-37: 147: 22.06
+	Hs
		468037 HS90B_HUMAN (19-732): 0: 1057: 86.13		FER_HUMAN (345-581): 4.36e-41: 161: 18.75
+	Hs
		136259 HS90A_HUMAN (1-732): 0: 1085: 100.00		P85B_HUMAN (292-581): 8.3e-32: 132: 17.15
+	Hs
		467980 HS90B_HUMAN (19-732): 0: 1057: 86.13		HCK_HUMAN (348-575): 6.63e-42: 160: 17.16
+	Hs
		468201 HS90B_HUMAN (19-732): 0: 1057: 86.13		BMX_HUMAN (341-582): 1.13e-38: 153: 19.69
+	Hs
		456084 HS90B_HUMAN (19-732): 0: 1057: 86.13		FES_HUMAN (326-581): 1.81e-37: 150: 21.79
+	Dm
		391909 HSP83_DROME (15-732): 0: 1031: 78.41		SRC42_DROME (351-579): 1.86e-39: 153: 18.07
+	Hs
		461342 HS90A_HUMAN (1-732): 0: 1085: 100.00		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Hs
		468251 HS90B_HUMAN (19-732): 0: 1057: 86.13		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Dm
		391876 HSP83_DROME (15-732): 0: 1031: 78.41		CSW_DROME (483-579): 2.72e-12: 71.8: 27.72
+	Hs
		473430 H90B3_HUMAN (19-732): 0: 728: 65.41		HCK_HUMAN (348-575): 6.63e-42: 160: 17.16
+	Hs
		908207 H90B3_HUMAN (19-732): 0: 728: 65.41		BMX_HUMAN (341-582): 1.13e-38: 153: 19.69