Protein: MARH5
E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)

Gene: MARH5, MARCHF5
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q9NX47

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

304886

MFN2
Mitofusin-2

8

3

Small-scale

0.751

High

919880

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

6

Small-scale

0.744

High

1284891

UBE2W
Ubiquitin-conjugating enzyme E2 W

4

7

High-throughput

0.700

High

1347753

MARH5
E3 ubiquitin-protein ligase MARCHF5

5

0

Small-scale

0.676

High

1218407

MFN1
Mitofusin-1

4

3

Small-scale

0.676

High

849461

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

6

Small-scale

0.655

High

128655

DNM1L
Dynamin-1-like protein

4

0

Small-scale

0.648

High

1190112

MAVS
Mitochondrial antiviral-signaling protein

4

0

Small-scale

0.648

High

1268950

AKAP1
A-kinase anchor protein 1, mitochondrial

3

1

Small-scale

0.640

High

1127330

TGO1
Transport and Golgi organization protein 1 homolog

3

0

High-throughput

0.638

High

1281123

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.601

High

297108

TOM70
Mitochondrial import receptor subunit TOM70

2

1

Small-scale

0.584

High

310841

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

1

Small-scale

0.584

High

1072892

MTFR1
Mitochondrial fission regulator 1

2

1

Small-scale

0.584

High

1220687

MIRO2
Mitochondrial Rho GTPase 2

2

1

Small-scale

0.584

High

1287201

FAF2
FAS-associated factor 2

2

1

Small-scale

0.584

High

1347766

TDRKH
Tudor and KH domain-containing protein

2

1

Small-scale

0.584

High

136228

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

303968

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

315076

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.580

High

873160

PTN5
Tyrosine-protein phosphatase non-receptor type 5

2

0

High-throughput

0.580

High

1021961

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.580

High

1101616

ODFP4
Outer dense fiber protein 4

2

0

High-throughput

0.580

High

1191219

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1217226

TM139
Transmembrane protein 139

2

0

High-throughput

0.580

High

1256203

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

1262915

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

2

0

High-throughput

0.580

High

1305538

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.580

High

1342985

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.580

High

1343442

MANBL
Protein MANBAL

2

0

High-throughput

0.580

High

1347765

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

657440

ABCD3
ATP-binding cassette sub-family D member 3

2

0

Small-scale

0.576

High

777272

PEX19
Peroxisomal biogenesis factor 19

2

0

Small-scale

0.576

High

881688

PEX3
Peroxisomal biogenesis factor 3

2

0

Small-scale

0.576

High

216852

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

504855

HSP7C
Heat shock cognate 71 kDa protein

2

0

Small-scale

0.559

High

573940

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

0

Small-scale

0.559

High

1173936

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

0

Small-scale

0.559

High

1239127

MIGA1
Mitoguardin 1

2

0

Small-scale

0.559

High

1283959

S2546
Mitochondrial outer membrane protein SLC25A46

2

0

Small-scale

0.559

High

1303185

RMD3
Regulator of microtubule dynamics protein 3

2

0

Small-scale

0.559

High

1326909

MFF
Mitochondrial fission factor

2

0

Small-scale

0.559

High

1347706

OCAD1
OCIA domain-containing protein 1

2

0

Small-scale

0.559

High

1291149

Q96FI0
N-terminal E2 ubiquitin-conjugating enzyme

2

6

High-throughput

0.558

High

867375

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.554

High

1217778

FUND1
FUN14 domain-containing protein 1

1

0

Small-scale

0.554

High

1345943

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

1342652

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

7

High-throughput

0.541

High

265561

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.537

High

336608

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.537

High

1185640

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1347760

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.513

High

807862

MAP1B
Microtubule-associated protein 1B

1

1

Small-scale

0.512

High

851894

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.501

High

895930

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

Small-scale

0.501

High

896552

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

7

High-throughput

0.494

High

930420

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.494

High

1333723

AKTIP
AKT-interacting protein

1

7

High-throughput

0.494

High

476468

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.493

High

1347767

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.493

High

1347761

DPOG2
DNA polymerase subunit gamma-2

1

0

Small-scale

0.480

High

228883

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.479

High

231173

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

Small-scale

0.479

High

259479

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.479

High

279733

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

330740

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

Small-scale

0.479

High

393372

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.479

High

432306

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

438566

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

561697

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

595442

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

800089

VDAC2
Voltage-dependent anion-selective channel protein 2

1

1

Small-scale

0.479

High

875364

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

1036944

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1052498

FLOT2
Flotillin-2

1

1

High-throughput

0.479

High

1159606

MTFR2
Mitochondrial fission regulator 2

1

1

High-throughput

0.479

High

1253737

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.479

High

1263730

SYNE2
Nesprin-2

1

1

High-throughput

0.479

High

1267617

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

1302275

TM209
Transmembrane protein 209

1

1

High-throughput

0.479

High

1308559

NIPS1
Protein NipSnap homolog 1

1

1

High-throughput

0.479

High

1346547

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.479

High

1346627

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

1347756

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

1347757

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

2

High-throughput

0.479

High

1347758

DNJB9
DnaJ homolog subfamily B member 9

1

1

Small-scale

0.479

High

170966

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.458

High

180945

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

196880

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.458

High

198734

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.458

High

262115

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

264107

TACC1
Transforming acidic coiled-coil-containing protein 1

1

0

High-throughput

0.458

High

296153

MTA2
Metastasis-associated protein MTA2

1

0

Small-scale

0.458

High

304371

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

307669

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

321942

RIGI
Antiviral innate immune response receptor RIG-I

1

0

Small-scale

0.458

High

330794

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.458

High

427931

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.458

High

531641

K2C5
Keratin, type II cytoskeletal 5

1

0

High-throughput

0.458

High

533880

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

High-throughput

0.458

High

538615

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

548963

NDKA
Nucleoside diphosphate kinase A

1

0

High-throughput

0.458

High

583377

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

607178

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

Small-scale

0.458

High

654838

CALX
Calnexin

1

0

Small-scale

0.458

High

681625

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.458

High

686204

GLPK
Glycerol kinase

1

0

High-throughput

0.458

High

840331

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.458

High

848981

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

858204

BIEA
Biliverdin reductase A

1

0

High-throughput

0.458

High

906931

PRS4
26S proteasome regulatory subunit 4

1

0

Small-scale

0.458

High

929083

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

941502

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

990709

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

994818

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.458

High

1040281

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1053222

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1055808

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

0

Small-scale

0.458

High

1056145

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1059283

GOGB1
Golgin subfamily B member 1

1

0

High-throughput

0.458

High

1062691

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1072839

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

1077729

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.458

High

1088677

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1135148

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1139452

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

Small-scale

0.458

High

1147942

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

Small-scale

0.458

High

1158928

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

Small-scale

0.458

High

1162954

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.458

High

1174201

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

0

Small-scale

0.458

High

1174863

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

1204475

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

1204606

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

1205079

VRK2
Serine/threonine-protein kinase VRK2

1

0

High-throughput

0.458

High

1224093

ELMD2
ELMO domain-containing protein 2

1

0

Small-scale

0.458

High

1234741

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.458

High

1283302

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1288744

S2538
Mitochondrial glycine transporter

1

0

Small-scale

0.458

High

1293060

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.458

High

1294070

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1301868

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1303940

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.458

High

1305117

DNJC7
DnaJ homolog subfamily C member 7

1

0

Small-scale

0.458

High

1305414

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

0

High-throughput

0.458

High

1315436

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.458

High

1330225

TMX1
Thioredoxin-related transmembrane protein 1

1

0

Small-scale

0.458

High

1343475

MID51
Mitochondrial dynamics protein MIEF1

1

0

High-throughput

0.458

High

1344326

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1346499

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1347754

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.458

High

1347755

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1347762

NB5R1
NADH-cytochrome b5 reductase 1

1

0

Small-scale

0.458

High

1347763

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

1347768

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.458

High

1347769

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.458

High

1282354

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

6

Small-scale

0.457

High

1103097

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.445

High

218079

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.437

High

422305

NFL
Neurofilament light polypeptide

1

1

High-throughput

0.437

High

1040777

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.437

High

1136988

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

High-throughput

0.437

High

1174188

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

1

Small-scale

0.437

High

1293582

GRM2B
GRAM domain-containing protein 2B

3

0

High-throughput

0.347

High

1347764

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

1031800

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1037751

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1147973

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

2

0

High-throughput

0.316

High

1328488

STMN4
Stathmin-4

2

0

High-throughput

0.316

High

1344208

SAR1A
Small COPII coat GTPase SAR1A

2

0

High-throughput

0.316

High

207748

DENR
Density-regulated protein

2

0

Small-scale

0.305

High

1271771

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.292

High

1044448

PTC1
Protein patched homolog 1

1

0

High-throughput

0.279

Low

1255285

GNPI2
Glucosamine-6-phosphate isomerase 2

1

0

High-throughput

0.279

Low

1347759

O12D3
Olfactory receptor 12D3

1

0

High-throughput

0.279

Low

232548

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.249

Low

260042

TBCA
Tubulin-specific chaperone A

1

0

Small-scale

0.249

Low

299735

SUN1
SUN domain-containing protein 1

1

0

High-throughput

0.249

Low

348049

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

472732

FBSP1
F-box/SPRY domain-containing protein 1

1

0

Small-scale

0.249

Low

553884

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

626268

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.249

Low

652422

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

868349

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

914401

RB11A
Ras-related protein Rab-11A

1

0

Small-scale

0.249

Low

915292

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

0

Small-scale

0.249

Low

925139

TRA2B
Transformer-2 protein homolog beta

1

0

Small-scale

0.249

Low

966660

OTUD4
OTU domain-containing protein 4

1

0

Small-scale

0.249

Low

1028851

SRSF5
Serine/arginine-rich splicing factor 5

1

0

Small-scale

0.249

Low

1084277

MEA1
Male-enhanced antigen 1

1

0

Small-scale

0.249

Low

1131029

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

1220825

ASXL1
Polycomb group protein ASXL1

1

0

Small-scale

0.249

Low

1223730

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.249

Low

1256832

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

1262138

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

Small-scale

0.249

Low

1273922

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.249

Low

1281142

NKD2
Protein naked cuticle homolog 2

1

0

Small-scale

0.249

Low

1287407

OPTN
Optineurin

1

0

High-throughput

0.249

Low

1297418

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1331099

TRABD
TraB domain-containing protein

1

0

High-throughput

0.249

Low

1331448

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1334704

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

1343495

DDX4
Probable ATP-dependent RNA helicase DDX4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024