Protein: P85B
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)

Gene: P85B, PIK3R2
Organism: Homo sapiens
Interactions: 235
UniProt ID: O00459

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0001784 - phosphotyrosine residue binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

136321

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

10

20

Small-scale

0.974

High

136243

EGFR
Epidermal growth factor receptor

11

20

Small-scale

0.973

High

136322

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

8

20

Small-scale

0.973

High

136297

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

9

19

Small-scale

0.969

High

136417

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

5

20

High-throughput

0.919

High

136250

ERBB2
Receptor tyrosine-protein kinase erbB-2

5

20

Small-scale

0.917

High

136329

CRK
Adapter molecule crk

5

20

High-throughput

0.915

High

136362

GRB2
Growth factor receptor-bound protein 2

4

20

High-throughput

0.903

High

136291

ERBB3
Receptor tyrosine-protein kinase erbB-3

4

20

Small-scale

0.899

High

136319

TGFR2
TGF-beta receptor type-2

4

13

Small-scale

0.895

High

136269

KIT
Mast/stem cell growth factor receptor Kit

3

20

Small-scale

0.843

High

136441

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

4

High-throughput

0.811

High

132781

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

2

20

Small-scale

0.806

High

136330

CRKL
Crk-like protein

2

20

Small-scale

0.806

High

136267

PGFRB
Platelet-derived growth factor receptor beta

3

20

Small-scale

0.805

High

136244

RASK
GTPase KRas

2

20

High-throughput

0.793

High

136389

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

20

Small-scale

0.789

High

136251

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.789

High

136262

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.783

High

136320

STAT3
Signal transducer and activator of transcription 3

2

20

High-throughput

0.767

High

136275

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.757

High

136299

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

136360

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

136293

CBL
E3 ubiquitin-protein ligase CBL

7

20

Small-scale

0.741

High

136306

UFO
Tyrosine-protein kinase receptor UFO

2

20

Small-scale

0.738

High

136263

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

136234

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.691

High

136253

INSR
Insulin receptor

1

20

High-throughput

0.691

High

136303

SHC1
SHC-transforming protein 1

1

19

High-throughput

0.691

High

136343

JAK3
Tyrosine-protein kinase JAK3

1

20

High-throughput

0.691

High

136349

ANM2
Protein arginine N-methyltransferase 2

1

6

High-throughput

0.691

High

136376

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.691

High

136230

IRS4
Insulin receptor substrate 4

3

20

High-throughput

0.675

High

136344

EFNB2
Ephrin-B2

3

9

High-throughput

0.667

High

136409

SKAP1
Src kinase-associated phosphoprotein 1

3

20

High-throughput

0.667

High

136377

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

Small-scale

0.659

High

136328

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.656

High

136255

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

136256

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.647

High

136271

GHR
Growth hormone receptor

1

20

Small-scale

0.647

High

136411

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

136379

DLG1
Disks large homolog 1

1

19

Small-scale

0.646

High

136239

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.646

High

136422

HAUS1
HAUS augmin-like complex subunit 1

3

0

High-throughput

0.638

High

136432

HAUS4
HAUS augmin-like complex subunit 4

3

0

High-throughput

0.638

High

136337

ARRB1
Beta-arrestin-1

2

9

High-throughput

0.633

High

136287

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.631

High

136403

RN19B
E3 ubiquitin-protein ligase RNF19B

2

13

High-throughput

0.628

High

136446

IKZF3
Zinc finger protein Aiolos

2

10

High-throughput

0.628

High

72375

A9UF07
Tyrosine-protein kinase ABL1

1

19

High-throughput

0.625

High

136323

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.621

High

136304

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

136448

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

126355

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

136229

SOCS6
Suppressor of cytokine signaling 6

1

19

Small-scale

0.618

High

136236

SOCS1
Suppressor of cytokine signaling 1

1

19

Small-scale

0.618

High

136242

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

136254

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

136260

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

136264

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

136273

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.618

High

136280

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.618

High

136281

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

136282

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.618

High

136284

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

136290

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.618

High

136300

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.618

High

136302

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

136316

VGFR3
Vascular endothelial growth factor receptor 3

1

20

High-throughput

0.618

High

136339

RAB7A
Ras-related protein Rab-7a

1

13

High-throughput

0.618

High

136342

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

136346

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

136351

ACTB
Actin, cytoplasmic 1

1

17

High-throughput

0.618

High

136352

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

136353

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

136354

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.618

High

136355

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

136356

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

136363

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

136368

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

136388

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

136392

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

136394

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

136406

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

136419

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

136435

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

136240

RCBT2
RCC1 and BTB domain-containing protein 2

3

6

High-throughput

0.609

High

136326

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

14

High-throughput

0.609

High

136450

GAB2
GRB2-associated-binding protein 2

2

20

High-throughput

0.601

High

136274

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

136310

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.584

High

136261

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.578

High

136445

DP13A
DCC-interacting protein 13-alpha

2

19

High-throughput

0.576

High

136276

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.575

High

136375

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.575

High

136397

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

136415

HAVR2
Hepatitis A virus cellular receptor 2

2

6

High-throughput

0.574

High

136434

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

136314

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.573

High

136317

TRI23
E3 ubiquitin-protein ligase TRIM23

1

9

High-throughput

0.573

High

136378

GOGA2
Golgin subfamily A member 2

1

17

High-throughput

0.573

High

136401

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.573

High

136288

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.571

High

136295

1433T
14-3-3 protein theta

1

20

Small-scale

0.561

High

136350

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

14

Small-scale

0.561

High

136444

FBXL2
F-box/LRR-repeat protein 2

1

8

Small-scale

0.561

High

71372

HECA2
HEPACAM family member 2

2

20

High-throughput

0.558

High

136289

EPHA1
Ephrin type-A receptor 1

1

20

High-throughput

0.553

High

136292

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

136301

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.553

High

136345

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

136371

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.553

High

136391

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.553

High

136393

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.553

High

136400

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.553

High

136404

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

136431

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

136235

COPT1
High affinity copper uptake protein 1

2

2

High-throughput

0.549

High

136268

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

136383

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

136249

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

136259

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

136266

CD7
T-cell antigen CD7

1

1

High-throughput

0.536

High

136327

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

136358

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.536

High

136361

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

136364

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

136367

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

136369

EFNB1
Ephrin-B1

1

9

High-throughput

0.536

High

136372

SEMG2
Semenogelin-2

1

1

High-throughput

0.536

High

136386

CUL3
Cullin-3

1

11

High-throughput

0.536

High

136402

PKN3
Serine/threonine-protein kinase N3

1

20

High-throughput

0.536

High

136420

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.536

High

136427

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

136436

WDR6
tRNA

1

15

High-throughput

0.536

High

136452

NISCH
Nischarin

1

11

High-throughput

0.536

High

136307

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.515

High

136428

MED28
Mediator of RNA polymerase II transcription subunit 28

1

11

Small-scale

0.515

High

136408

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

20

High-throughput

0.515

High

136252

A4
Amyloid-beta precursor protein

1

19

High-throughput

0.501

High

136298

GRN
Progranulin

1

1

High-throughput

0.494

High

136334

V1BR
Vasopressin V1b receptor

1

14

High-throughput

0.489

High

136413

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

136454

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

136246

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.481

High

136348

LAMB2
Laminin subunit beta-2

1

6

High-throughput

0.481

High

136228

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

High-throughput

0.479

High

136231

AURKA
Aurora kinase A

1

20

High-throughput

0.479

High

136232

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

136238

FLOT1
Flotillin-1

1

11

High-throughput

0.479

High

136245

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

136247

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

136248

K2C1
Keratin, type II cytoskeletal 1

1

18

High-throughput

0.479

High

136257

TBB5
Tubulin beta chain

1

16

High-throughput

0.479

High

136265

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.479

High

136270

CD28
T-cell-specific surface glycoprotein CD28

1

11

Small-scale

0.479

High

136272

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

136277

ITA4
Integrin alpha-4

1

10

High-throughput

0.479

High

136278

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.479

High

136279

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.479

High

136283

HSP76
Heat shock 70 kDa protein 6

1

20

High-throughput

0.479

High

136285

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

136286

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

20

High-throughput

0.479

High

136296

DPP4
Dipeptidyl peptidase 4

1

5

High-throughput

0.479

High

136305

MARCS
Myristoylated alanine-rich C-kinase substrate

1

20

High-throughput

0.479

High

136308

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

136309

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

136311

MYH9
Myosin-9

1

13

High-throughput

0.479

High

136312

MYH10
Myosin-10

1

13

High-throughput

0.479

High

136313

FUS
RNA-binding protein FUS

1

10

High-throughput

0.479

High

136315

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.479

High

136318

TGFR1
TGF-beta receptor type-1

1

13

Small-scale

0.479

High

136331

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

136332

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.479

High

136333

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

High-throughput

0.479

High

136336

K2C6C
Keratin, type II cytoskeletal 6C

1

18

High-throughput

0.479

High

136340

CCR5
C-C chemokine receptor type 5

1

14

Small-scale

0.479

High

136341

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

11

High-throughput

0.479

High

136347

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

136359

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

136365

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

136370

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.479

High

136373

CAV1
Caveolin-1

1

15

High-throughput

0.479

High

136374

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.479

High

136380

ACACA
Acetyl-CoA carboxylase 1

1

7

High-throughput

0.479

High

136381

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

136382

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

136384

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.479

High

136385

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

136390

KS6A2
Ribosomal protein S6 kinase alpha-2

1

20

High-throughput

0.479

High

136398

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.479

High

136407

MYH14
Myosin-14

1

13

High-throughput

0.479

High

136424

DNJC7
DnaJ homolog subfamily C member 7

1

14

High-throughput

0.479

High

136425

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.479

High

136426

TBB6
Tubulin beta-6 chain

1

16

High-throughput

0.479

High

136430

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

136433

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

136437

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

136443

XPO7
Exportin-7

1

6

High-throughput

0.479

High

136447

COR1C
Coronin-1C

1

10

High-throughput

0.479

High

136453

NINL
Ninein-like protein

1

19

High-throughput

0.479

High

109342

G5E9A7
DM1 locus, WD repeat containing

1

14

High-throughput

0.470

High

136357

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

136414

ENKUR
Enkurin

1

1

Small-scale

0.457

High

136324

HD
Huntingtin

1

8

High-throughput

0.457

High

136294

CCND1
G1/S-specific cyclin-D1

1

5

High-throughput

0.445

High

136387

SL9A5
Sodium/hydrogen exchanger 5

1

5

High-throughput

0.445

High

136396

MK06
Mitogen-activated protein kinase 6

1

9

High-throughput

0.445

High

136457

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

6

High-throughput

0.445

High

136438

LTBP3
Latent-transforming growth factor beta-binding protein 3

1

14

High-throughput

0.439

High

136440

STAB1
Stabilin-1

1

10

High-throughput

0.439

High

136237

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

136258

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

4

Small-scale

0.437

High

136338

R144A
E3 ubiquitin-protein ligase RNF144A

1

8

Small-scale

0.437

High

136366

CXAR
Coxsackievirus and adenovirus receptor

1

16

High-throughput

0.437

High

136395

OCLN
Occludin

1

6

High-throughput

0.437

High

136399

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

136418

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

136421

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

136439

RED2
Double-stranded RNA-specific editase B2

1

5

High-throughput

0.437

High

136442

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.437

High

136451

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

20

High-throughput

0.437

High

136233

S22A2
Solute carrier family 22 member 2

1

5

High-throughput

0.407

High

136325

EAA1
Excitatory amino acid transporter 1

1

7

High-throughput

0.407

High

136335

EAA4
Excitatory amino acid transporter 4

1

7

High-throughput

0.407

High

136410

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

9

High-throughput

0.407

High

136412

LAT4
Large neutral amino acids transporter small subunit 4

1

2

High-throughput

0.407

High

136429

RHBG
Ammonium transporter Rh type B

1

3

High-throughput

0.407

High

136449

S12A4
Solute carrier family 12 member 4

1

14

High-throughput

0.407

High

136455

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

9

High-throughput

0.407

High

136456

S4A7
Sodium bicarbonate cotransporter 3

1

6

High-throughput

0.407

High

136423

MR1L1
MORF4 family-associated protein 1-like 1

2

0

High-throughput

0.334

High

136416

DYDC1
DPY30 domain-containing protein 1

1

0

High-throughput

0.299

High

136241

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.279

Low

136405

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025