HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051726 - regulation of cell cycle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 424
+	Hs
		461436 HS90A_HUMAN (1-724): 0: 1069: 85.25		SKP2_HUMAN (1-424): 9.96e-97: 297: 100.00
+	Hs
		468900 HS90B_HUMAN (1-724): 0: 1083: 100.00		FBXL2_HUMAN (112-418): 3.48e-33: 131: 17.60
+	Hs
		462029 HS90A_HUMAN (1-724): 0: 1069: 85.25		FBXL2_HUMAN (112-418): 3.48e-33: 131: 17.60
+	Hs
		468585 HS90B_HUMAN (1-724): 0: 1083: 100.00		FXL14_HUMAN (160-393): 8.43e-25: 107: 19.11
+	Hs
		468801 HS90B_HUMAN (1-724): 0: 1083: 100.00		FXL15_HUMAN (85-361): 7.44e-25: 105: 21.28
+	Hs
		468853 HS90B_HUMAN (1-724): 0: 1083: 100.00		FXL12_HUMAN (99-385): 2.57e-21: 96: 23.89
+	Hs
		461695 HS90A_HUMAN (1-724): 0: 1069: 85.25		FXL14_HUMAN (160-393): 8.43e-25: 107: 19.11
+	Hs
		461931 HS90A_HUMAN (1-724): 0: 1069: 85.25		FXL15_HUMAN (85-361): 7.44e-25: 105: 21.28
+	Hs
		461982 HS90A_HUMAN (1-724): 0: 1069: 85.25		FXL12_HUMAN (99-385): 2.57e-21: 96: 23.89
+	Hs
		468898 HS90B_HUMAN (1-724): 0: 1083: 100.00		FBXL4_HUMAN (159-424): 1.23e-14: 77.9: 17.73
+	Hs
		468607 HS90B_HUMAN (1-724): 0: 1083: 100.00		FXL13_HUMAN (189-369): 3.31e-14: 76.7: 16.22
+	Hs
		462027 HS90A_HUMAN (1-724): 0: 1069: 85.25		FBXL4_HUMAN (159-424): 1.23e-14: 77.9: 17.73
+	Hs
		468592 HS90B_HUMAN (1-724): 0: 1083: 100.00		FBXL6_HUMAN (112-346): 4.61e-10: 63.2: 15.44
+	Hs
		461721 HS90A_HUMAN (1-724): 0: 1069: 85.25		FXL13_HUMAN (189-369): 3.31e-14: 76.7: 16.22
+	Hs
		461703 HS90A_HUMAN (1-724): 0: 1069: 85.25		FBXL6_HUMAN (112-346): 4.61e-10: 63.2: 15.44
+	Hs
		1245560 Q6PK50_HUMAN (1-350): 0: 618: 99.71		FXL14_HUMAN (160-393): 8.43e-25: 107: 19.11
+	Hs
		75449 Q6PK50_HUMAN (1-350): 0: 618: 99.71		B3KM70_HUMAN (110-354): 8.48e-24: 104: 18.68