Protein: FXL12
F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)

Gene: FXL12, FBXL12
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q9NXK8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992358

SKP1
S-phase kinase-associated protein 1

12

20

Small-scale

0.978

High

1112743

CUL1
Cullin-1

8

20

Small-scale

0.964

High

1356798

STYX
Serine/threonine/tyrosine-interacting protein

4

3

Small-scale

0.686

High

960589

PSME3
Proteasome activator complex subunit 3

2

3

Small-scale

0.639

High

1338521

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.618

High

831534

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

1452052

FXL12
F-box/LRR-repeat protein 12

1

7

Small-scale

0.618

High

944575

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.580

High

1348544

LNX1
E3 ubiquitin-protein ligase LNX

1

1

High-throughput

0.573

High

606043

CAN2
Calpain-2 catalytic subunit

2

1

Small-scale

0.571

High

722817

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

3

Small-scale

0.561

High

808181

CDN1A
Cyclin-dependent kinase inhibitor 1

1

7

Small-scale

0.561

High

1429655

RNF32
RING finger protein 32

1

0

High-throughput

0.543

High

1353150

FBF1
Fas-binding factor 1

1

5

High-throughput

0.541

High

983991

RBX1
E3 ubiquitin-protein ligase RBX1

1

10

Small-scale

0.536

High

1272576

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.536

High

1158576

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

656026

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

1413868

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1452056

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1410333

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.504

High

957218

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

890779

PSN2
Presenilin-2

1

1

High-throughput

0.494

High

1452054

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.494

High

774666

BASI
Basigin

1

1

High-throughput

0.489

High

1452055

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

1452057

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

1452058

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

892757

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

6

Small-scale

0.488

High

166575

BACH1
Transcription regulator protein BACH1

1

20

Small-scale

0.479

High

457137

CAN1
Calpain-1 catalytic subunit

1

1

Small-scale

0.479

High

461982

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.479

High

468853

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

479879

GSTP1
Glutathione S-transferase P

1

2

Small-scale

0.479

High

562656

RINI
Ribonuclease inhibitor

1

9

Small-scale

0.479

High

848083

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

3

Small-scale

0.479

High

906199

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

3

Small-scale

0.479

High

1098889

SLAP1
Src-like-adapter

1

3

Small-scale

0.479

High

456869

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

1178425

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1397492

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1435365

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

457742

TBB5
Tubulin beta chain

1

5

High-throughput

0.445

High

635393

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

High-throughput

0.445

High

1227574

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

890060

PSN1
Presenilin-1

1

1

High-throughput

0.439

High

430434

JUN
Transcription factor Jun

1

2

Small-scale

0.437

High

1007614

PRAME
Melanoma antigen preferentially expressed in tumors

1

4

Small-scale

0.437

High

1145699

RCN1
Reticulocalbin-1

1

1

Small-scale

0.437

High

1242099

TTC27
Tetratricopeptide repeat protein 27

1

3

Small-scale

0.437

High

844885

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1132586

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.282

High

260976

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

582364

ARSA
Arylsulfatase A

1

0

High-throughput

0.279

Low

933235

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1349137

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1452053

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

369762

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.251

Low

387472

APOE
Apolipoprotein E

1

0

High-throughput

0.251

Low

271200

ASTN2
Astrotactin-2

1

0

Small-scale

0.249

Low

294427

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1207017

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

Small-scale

0.249

Low

1413832

HGH1
Protein HGH1 homolog

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025