Protein: FXL14
F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)

Gene: FXL14, FBXL14
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q8N1E6

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0019005 - SCF ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992251

SKP1
S-phase kinase-associated protein 1

6

20

High-throughput

0.948

High

1112595

CUL1
Cullin-1

6

20

Small-scale

0.947

High

920478

DAPK1
Death-associated protein kinase 1

1

4

High-throughput

0.692

High

350068

SNAI1
Zinc finger protein SNAI1

4

2

Small-scale

0.692

High

1323395

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.691

High

1272481

CSN6
COP9 signalosome complex subunit 6

3

1

High-throughput

0.675

High

1323403

DICER
Endoribonuclease Dicer

3

1

Small-scale

0.667

High

958668

CSN2
COP9 signalosome complex subunit 2

3

3

High-throughput

0.662

High

1182842

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

20

High-throughput

0.647

High

348286

QORL1
Quinone oxidoreductase-like protein 1

2

3

High-throughput

0.628

High

776986

PPM1A
Protein phosphatase 1A

2

1

High-throughput

0.628

High

1094368

CSN1
COP9 signalosome complex subunit 1

2

1

High-throughput

0.628

High

1323393

CSN5
COP9 signalosome complex subunit 5

2

1

High-throughput

0.628

High

1323402

CSN3
COP9 signalosome complex subunit 3

2

3

High-throughput

0.628

High

1323404

SGT1
Protein SGT1 homolog

2

9

High-throughput

0.628

High

1323405

DAAM1
Disheveled-associated activator of morphogenesis 1

2

3

High-throughput

0.628

High

1154391

STK11
Serine/threonine-protein kinase STK11

1

3

Small-scale

0.618

High

1243890

AAGAB
Alpha- and gamma-adaptin-binding protein p34

2

0

High-throughput

0.602

High

1323400

CSN7A
COP9 signalosome complex subunit 7a

2

0

High-throughput

0.602

High

1047842

TLE1
Transducin-like enhancer protein 1

2

5

High-throughput

0.601

High

138851

STK25
Serine/threonine-protein kinase 25

1

4

High-throughput

0.575

High

1129009

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

2

1

High-throughput

0.574

High

1323391

TTC9C
Tetratricopeptide repeat protein 9C

2

3

High-throughput

0.574

High

1323398

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

1

High-throughput

0.574

High

994932

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

1

High-throughput

0.549

High

984191

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.536

High

1323392

STYX
Serine/threonine/tyrosine-interacting protein

1

1

High-throughput

0.536

High

461695

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.479

High

468585

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

983880

RBX1
E3 ubiquitin-protein ligase RBX1

1

8

Small-scale

0.479

High

1105997

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.479

High

1126799

HES1
Transcription factor HES-1

1

1

Small-scale

0.479

High

1323397

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

67560

MYH7B
Myosin-7B

1

3

High-throughput

0.445

High

437592

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

10

High-throughput

0.445

High

556864

MYH1
Myosin-1

1

3

High-throughput

0.445

High

563022

MYH6
Myosin-6

1

3

High-throughput

0.445

High

960486

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.445

High

1323396

MTA3
Metastasis-associated protein MTA3

1

1

Small-scale

0.445

High

1323401

MYH2
Myosin-2

1

3

High-throughput

0.445

High

76555

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

8

High-throughput

0.437

High

372553

MYC
Myc proto-oncogene protein

1

5

Small-scale

0.437

High

1245560

Q6PK50
HSP90AB1 protein

1

11

High-throughput

0.437

High

1136138

SPCS2
Signal peptidase complex subunit 2

3

0

High-throughput

0.345

High

1251828

PPR21
Protein phosphatase 1 regulatory subunit 21

2

0

High-throughput

0.328

High

1323406

SPCS1
Signal peptidase complex subunit 1

2

0

High-throughput

0.313

High

1087065

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.279

Low

1151964

TWST1
Twist-related protein 1

1

0

Small-scale

0.249

Low

1323394

NIPS1
Protein NipSnap homolog 1

1

0

Small-scale

0.249

Low

1323399

CDCP1
CUB domain-containing protein 1

1

0

Small-scale

0.249

Low

1017791

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025