Protein: Q6PK50
HSP90AB1 protein

Gene: Q6PK50, HSP90AB1
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q6PK50

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0016887 - ATP hydrolysis activity
GO:0051082 - unfolded protein binding
GO:0140662 - ATP-dependent protein folding chaperone

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

75482

B3KQG4
non-specific serine/threonine protein kinase

1

15

High-throughput

0.618

High

179616

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

20

High-throughput

0.618

High

363437

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

364150

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

8

High-throughput

0.618

High

401013

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

410905

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

461607

HS90A
Heat shock protein HSP 90-alpha

1

18

High-throughput

0.618

High

897868

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.618

High

1038644

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.618

High

1122511

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

High-throughput

0.618

High

1143029

CDK10
Cyclin-dependent kinase 10

1

19

High-throughput

0.618

High

1144037

TEBP
Prostaglandin E synthase 3

1

8

High-throughput

0.618

High

1154380

STK11
Serine/threonine-protein kinase STK11

1

16

High-throughput

0.618

High

1155119

Q15850
receptor protein-tyrosine kinase

1

20

High-throughput

0.618

High

1158389

CDC37
Hsp90 co-chaperone Cdc37

1

18

High-throughput

0.618

High

1201611

Q573B4
Tyrosine-protein kinase

1

20

High-throughput

0.618

High

1202573

Q59GL9
IkappaB kinase

1

20

High-throughput

0.618

High

1202593

Q59GT1
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.618

High

1214475

Q5T853
Mitogen-activated protein kinase kinase kinase 8

1

3

High-throughput

0.618

High

1235995

Q6LC83
Cyclin-dependent kinase 4

1

20

High-throughput

0.618

High

1245550

KSR2
Kinase suppressor of Ras 2

1

20

High-throughput

0.618

High

1245553

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

15

High-throughput

0.618

High

1245566

AURKB
Aurora kinase B

1

20

High-throughput

0.618

High

1245567

Q96II5
non-specific serine/threonine protein kinase

1

20

High-throughput

0.618

High

1245570

TESK2
Dual specificity testis-specific protein kinase 2

1

18

High-throughput

0.618

High

1245573

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

17

High-throughput

0.618

High

1245581

E2AK4
eIF-2-alpha kinase GCN2

1

20

High-throughput

0.618

High

1245584

Q9UMP2
DNA mismatch repair protein

1

6

High-throughput

0.618

High

1245587

AKT3
RAC-gamma serine/threonine-protein kinase

1

20

High-throughput

0.618

High

76546

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

20

High-throughput

0.553

High

322954

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

10

High-throughput

0.553

High

1122904

SIM2
Single-minded homolog 2

1

18

High-throughput

0.553

High

1125493

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.553

High

1245571

Q9BPW0
Serine/threonine-protein phosphatase

1

14

High-throughput

0.553

High

1245575

RPAP3
RNA polymerase II-associated protein 3

1

20

High-throughput

0.553

High

611677

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

4

High-throughput

0.479

High

947356

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

14

High-throughput

0.479

High

1180057

Q2TAK1
F-box DNA helicase 1

1

2

High-throughput

0.479

High

1245556

Q86WA0
ATP-dependent RNA helicase TDRD9

1

7

High-throughput

0.479

High

1245565

Q93000
CHL1 protein

1

4

High-throughput

0.479

High

1245586

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

14

High-throughput

0.479

High

69427

A8K251
Zinc finger and BTB domain-containing protein 20

1

6

High-throughput

0.437

High

75449

B3KM70
cDNA FLJ10409 fis, clone NT2RM4000595, highly similar to F-box/LRR-repeat protein 2

1

16

High-throughput

0.437

High

75882

B4DE84
cDNA FLJ55955, highly similar to HECT domain and RCC1-like domain-containing protein 2

1

1

High-throughput

0.437

High

163645

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

11

High-throughput

0.437

High

165049

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.437

High

193025

CFLAR
CASP8 and FADD-like apoptosis regulator

1

2

High-throughput

0.437

High

207966

TET3
Methylcytosine dioxygenase TET3

1

8

High-throughput

0.437

High

271330

ZBED4
Zinc finger BED domain-containing protein 4

1

6

High-throughput

0.437

High

281499

FBX24
F-box only protein 24

1

2

High-throughput

0.437

High

587392

RAG1
V(D)J recombination-activating protein 1

1

20

High-throughput

0.437

High

623394

RO52
E3 ubiquitin-protein ligase TRIM21

1

16

High-throughput

0.437

High

799628

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

1

3

High-throughput

0.437

High

889367

RGS6
Regulator of G-protein signaling 6

1

9

High-throughput

0.437

High

1007571

PRAME
Melanoma antigen preferentially expressed in tumors

1

9

High-throughput

0.437

High

1025884

FANCC
Fanconi anemia group C protein

1

3

High-throughput

0.437

High

1115256

CUL4B
Cullin-4B

1

20

High-throughput

0.437

High

1139742

SETB1
Histone-lysine N-methyltransferase SETDB1

1

10

High-throughput

0.437

High

1180781

KLH38
Kelch-like protein 38

1

20

High-throughput

0.437

High

1186259

Q3KQR5
C20orf194 protein

1

2

High-throughput

0.437

High

1187840

FX4L6
Forkhead box protein D4-like 6

1

2

High-throughput

0.437

High

1187941

Q3SYG0
PR domain zinc finger protein 1

1

3

High-throughput

0.437

High

1194778

Q4G1B2
Regulator of G-protein signaling 9

1

9

High-throughput

0.437

High

1196056

Q4TT70
Regulator of G-protein signaling 11

1

9

High-throughput

0.437

High

1200039

EIPR1
EARP and GARP complex-interacting protein 1

1

10

High-throughput

0.437

High

1200617

Q53XS2
Ectodermal-neural cortex

1

20

High-throughput

0.437

High

1202553

Q59FP4
Integrin-linked kinase variant

1

3

High-throughput

0.437

High

1204650

TFDP3
Transcription factor Dp family member 3

1

2

High-throughput

0.437

High

1215030

Q5TA56
Argonaute RISC catalytic component 3

1

20

High-throughput

0.437

High

1232389

Q6FHM2
Epididymis secretory sperm binding protein

1

13

High-throughput

0.437

High

1245551

NHLC1
E3 ubiquitin-protein ligase NHLRC1

1

9

High-throughput

0.437

High

1245552

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

7

High-throughput

0.437

High

1245554

DET1
DET1 homolog

1

3

High-throughput

0.437

High

1245555

PIWL4
Piwi-like protein 4

1

20

High-throughput

0.437

High

1245557

Q86WI5
F-box and WD-repeat protein 1B isoform 2

1

4

High-throughput

0.437

High

1245558

CC117
Coiled-coil domain-containing protein 117

1

3

High-throughput

0.437

High

1245559

UN45B
Protein unc-45 homolog B

1

20

High-throughput

0.437

High

1245560

FXL14
F-box/LRR-repeat protein 14

1

11

High-throughput

0.437

High

1245562

CTCFL
Transcriptional repressor CTCFL

1

3

High-throughput

0.437

High

1245563

PIWL2
Piwi-like protein 2

1

20

High-throughput

0.437

High

1245564

FBX25
F-box only protein 25

1

3

High-throughput

0.437

High

1245568

PIWL1
Piwi-like protein 1

1

20

High-throughput

0.437

High

1245572

TRI56
E3 ubiquitin-protein ligase TRIM56

1

19

High-throughput

0.437

High

1245576

Q9H9C5
Ubiquitin carboxyl-terminal hydrolase

1

2

High-throughput

0.437

High

1245577

SEC12
Guanine nucleotide-exchange factor SEC12

1

13

High-throughput

0.437

High

1245578

KLHL1
Kelch-like protein 1

1

20

High-throughput

0.437

High

1245580

WSB2
WD repeat and SOCS box-containing protein 2

1

17

High-throughput

0.437

High

1245582

HDAC6
Protein deacetylase HDAC6

1

17

High-throughput

0.437

High

1245583

FBXW2
F-box/WD repeat-containing protein 2

1

18

High-throughput

0.437

High

1245585

UBP18
Ubl carboxyl-terminal hydrolase 18

1

7

High-throughput

0.437

High

1245588

TRI17
E3 ubiquitin-protein ligase TRIM17

1

16

High-throughput

0.437

High

1200201

Q53HY9
PADI4 protein

1

0

High-throughput

0.249

Low

1216700

Q5TZT0
exodeoxyribonuclease III

1

0

High-throughput

0.249

Low

1217240

Q5ULA9
Monoamine oxidase A

1

0

High-throughput

0.249

Low

1245561

ZN843
Zinc finger protein 843

1

0

High-throughput

0.249

Low

1245569

Q96PK0
COPG2

1

0

High-throughput

0.249

Low

1245574

Q9H4M8
PAR2

1

0

High-throughput

0.249

Low

1245579

Q9NWG3
cDNA FLJ10043 fis, clone HEMBA1001085

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025