HitPredict

Interactor 1: MYL3 (P08590)
Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)
Gene: MYL3

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34535262
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003774 - cytoskeletal motor activity GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0007519 - skeletal muscle tissue development GO:0008307 - structural constituent of muscle and 1 others more... GO:0016460 - myosin II complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 195 Hs			1 151
+	Hs
		437562 MYL1_HUMAN (34-194): 7.26e-69: 209: 75.16		MYL4_HUMAN (3-151): 2.19e-57: 179: 77.48
+	Hs
		472232 MYL3_HUMAN (1-195): 2.42e-59: 185: 100.00		MYL4_HUMAN (3-151): 2.19e-57: 179: 77.48
+	Mm
		483494 MYL3_MOUSE (28-195): 7.05e-60: 187: 96.43		MYL3_MOUSE (3-150): 8.58e-56: 175: 74.00
+	Mm
		1423901 Q9CZ19_MOUSE (33-194): 2.29e-57: 180: 77.78		Q9CZ19_MOUSE (3-151): 9.14e-57: 177: 74.17
+	At
		515564 CDPKU_ARATH (6-194): 6.02e-52: 176: 22.05		CALM4_ARATH (3-150): 1.15e-44: 145: 44.30
+	At
		1043103 CDPKU_ARATH (6-194): 6.02e-52: 176: 22.05		CALM6_ARATH (3-150): 2.34e-44: 144: 44.30
+	At
		947591 CDPKU_ARATH (6-194): 6.02e-52: 176: 22.05		CALM7_ARATH (3-150): 1.9e-44: 144: 44.97
+	Hs
		573939 MYL6_HUMAN (45-194): 9e-55: 172: 73.33		MYL6B_HUMAN (3-150): 1.49e-44: 146: 81.76
+	Hs
		952530 MYL6_HUMAN (45-194): 9e-55: 172: 73.33		MYL6_HUMAN (1-151): 9.74e-44: 143: 100.00
+	Hs
		437557 MYL1_HUMAN (34-194): 7.26e-69: 209: 75.16		CALM1_HUMAN (5-77): 1.96e-12: 62.5: 28.77
+	Hs
		437558 MYL1_HUMAN (34-194): 7.26e-69: 209: 75.16		CALM3_HUMAN (5-77): 1.96e-12: 62.5: 28.77
+	At
		1183276 CDPKB_ARATH (7-194): 1.01e-53: 180: 20.73		CDPKB_ARATH (73-146): 2.06e-10: 59.4: 22.67
+	At
		1182290 CDPK4_ARATH (7-194): 8.38e-54: 180: 21.24		CDPK4_ARATH (15-146): 1.18e-09: 57.1: 16.43
+	At
		1057375 CDPK1_ARATH (7-194): 7.42e-53: 179: 20.73		CDPK1_ARATH (73-146): 9.65e-10: 57.5: 21.33
+	Hs
		516323 MYL6_HUMAN (45-194): 9e-55: 172: 73.33		CALM1_HUMAN (5-77): 1.96e-12: 62.5: 28.77
+	Hs
		516397 MYL6_HUMAN (45-194): 9e-55: 172: 73.33		CALM2_HUMAN (5-77): 1.96e-12: 62.5: 28.77
+	Hs
		516488 MYL6_HUMAN (45-194): 9e-55: 172: 73.33		CALM3_HUMAN (5-77): 1.96e-12: 62.5: 28.77
+	Hs
		516305 MYL6B_HUMAN (1-194): 6.81e-52: 167: 57.90		CALM1_HUMAN (5-77): 1.96e-12: 62.5: 28.77