Protein: MYL1
Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2)

Gene: MYL1
Organism: Homo sapiens
Interactions: 65
UniProt ID: P05976

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005859 - muscle myosin complex
GO:0006936 - muscle contraction
GO:0008307 - structural constituent of muscle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437585

HIF1A
Hypoxia-inducible factor 1-alpha

2

3

High-throughput

0.628

High

348935

LATS1
Serine/threonine-protein kinase LATS1

2

5

High-throughput

0.611

High

437556

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

6

High-throughput

0.602

High

437577

TLE3
Transducin-like enhancer protein 3

2

3

High-throughput

0.574

High

437584

ANKR1
Ankyrin repeat domain-containing protein 1

1

3

High-throughput

0.541

High

168614

CSKP
Peripheral plasma membrane protein CASK

1

16

High-throughput

0.536

High

276659

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

2

High-throughput

0.536

High

437562

MYL4
Myosin light chain 4

1

17

High-throughput

0.536

High

437565

ML12A
Myosin regulatory light chain 12A

1

20

High-throughput

0.536

High

437569

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

2

High-throughput

0.536

High

437573

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

437576

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.536

High

437606

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

220141

TNF14
Tumor necrosis factor ligand superfamily member 14

1

2

High-throughput

0.489

High

437588

COX15
Heme A synthase COX15

1

1

High-throughput

0.489

High

437597

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.489

High

437607

RBMX2
RNA-binding motif protein, X-linked 2

1

3

High-throughput

0.489

High

421300

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

271819

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

437560

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

437564

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.479

High

437567

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

437568

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.479

High

437572

MYH10
Myosin-10

1

19

High-throughput

0.479

High

437575

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

437579

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

437581

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

437582

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

437583

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

437593

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

437595

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

437596

OPTN
Optineurin

1

20

High-throughput

0.479

High

437599

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

437604

DUX4
Double homeobox protein 4

1

4

High-throughput

0.479

High

437605

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

437600

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

437601

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

169041

ML12B
Myosin regulatory light chain 12B

1

19

High-throughput

0.445

High

437557

CALM1
Calmodulin-1

1

17

High-throughput

0.445

High

437558

CALM3
Calmodulin-3

1

17

High-throughput

0.445

High

437559

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

437570

S10A4
Protein S100-A4

1

3

High-throughput

0.445

High

437571

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

437587

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

13

High-throughput

0.445

High

437590

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

20

High-throughput

0.445

High

437592

FXL14
F-box/LRR-repeat protein 14

1

10

High-throughput

0.445

High

437602

RNF12
E3 ubiquitin-protein ligase RLIM

1

7

High-throughput

0.445

High

388895

FINC
Fibronectin

1

2

High-throughput

0.437

High

437555

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.437

High

437566

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.437

High

437580

CUL4A
Cullin-4A

1

7

High-throughput

0.437

High

437591

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

437594

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

437574

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

Small-scale

0.408

High

346588

TTC4
Tetratricopeptide repeat protein 4

1

1

High-throughput

0.407

High

437608

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.407

High

65962

CCD69
Coiled-coil domain-containing protein 69

1

0

High-throughput

0.279

Low

166606

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

437589

TSN33
Tetraspanin-33

1

0

High-throughput

0.279

Low

437598

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.279

Low

437561

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

437563

H12
Histone H1.2

1

0

High-throughput

0.249

Low

437603

TM260
Protein O-mannosyl-transferase TMEM260

1

0

High-throughput

0.249

Low

437578

MFGM
Lactadherin

1

0

High-throughput

0.232

Low

437586

RSPO1
R-spondin-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025